Table 3.
Type of Infection Among Patients Hospitalized With Bloodstream Infection
| TT (n = 1 733) | TC (n = 830) | CC (n = 130) | Additive | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number of Events (n = 2 693) | n (%) | n (%) | OR (95% CI) | P Value | n (%) | OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Type of infecting bacteria | ||||||||||
| Gram-negative | 1 541 (57.2) | 996 (57.5) | 464 (55.9) | 0.94 (.80–1.12) | .491 | 81 (62.3) | 1.22 (.84–1.76) | .300 | 1.01 (.88–1.15) | .913 |
| Gram-positive | 1 145 (42.5) | 733 (42.3) | 363 (43.7) | 1.06 (.89–1.25) | .529 | 49 (37.7) | 0.83 (.57–1.20) | .325 | 0.99 (.87–1.14) | .921 |
| Streptococcus pneumoniae | 278 (10.3) | 185 (10.7) | 78 (9.4) | 0.87 (.66–1.15) | .314 | 15 (11.5) | 1.12 (.64–1.96) | .690 | 0.96 (.77–1.20) | .721 |
| Staphylococcus aureus | 330 (12.3) | 201 (11.6) | 119 (14.3) | 1.26 (.99–1.61) | .061 | 10 (7.7) | 0.63 (.33–1.23) | .177 | 1.05 (.86–1.28) | .649 |
| Enterococcus faecalis | 110 (4.1) | 72 (4.2) | 34 (4.1) | 0.98 (.64–1.49) | .923 | 4 (3.1) | 0.72 (.26–2.00) | .526 | 0.94 (.66–1.32) | .703 |
| Escherichia coli | 751 (27.9) | 487 (28.1) | 226 (27.2) | 0.96 (.80–1.16) | .685 | 38 (29.2) | 1.06 (.71–1.57) | .776 | 0.99 (.85–1.15) | .898 |
| Origin of infection | ||||||||||
| Lower respiratory tract | 480 (17.8) | 314 (18.1) | 144 (17.4) | 0.95 (.76–1.18) | .621 | 22 (16.9) | 0.89 (.55–1.44) | .637 | 0.96 (.80–1.14) | .610 |
| Urinary tract | 585 (21.7) | 376 (21.7) | 187 (22.5) | 1.05 (.86–1.28) | .637 | 22 (16.9) | 0.74 (.46–1.19) | .218 | 0.97 (.83–1.14) | .743 |
| Gastrointestinal | 225 (8.4) | 141 (8.1) | 67 (8.1) | 0.99 (.73–1.34) | .960 | 17 (13.1) | 1.67 (.97–2.86) | .063 | 1.14 (.91–1.44) | .264 |
| Skin | 117 (4.3) | 80 (4.6) | 30 (3.6) | 0.77 (.50–1.19) | .243 | 7 (5.4) | 1.20 (.54–2.66) | .653 | 0.93 (.66–1.29) | .648 |
| Other | 727 (27.0) | 463 (26.7) | 230 (27.7) | 1.05 (.88–1.27) | .573 | 34 (26.2) | 0.99 (.66–1.48) | .944 | 1.02 (.88–1.18) | .806 |
| Severity of infection | ||||||||||
| Sepsis not diagnosed | 1 306 (48.5) | 837 (48.3) | 396 (47.7) | 1.02 (.87–1.20) | .797 | 73 (56.2) | 0.70 (.49–.99) | .046 | 0.94 (.82–1.06) | .307 |
| Sepsis | 1 158 (43.0) | 747 (43.1) | 360 (43.4) | 51 (39.2) | ||||||
| Severe sepsis | 229 (8.5) | 149 (8.6) | 74 (8.9) | 6 (4.6) | ||||||
| Death within 30 days | 444 (16.6) | 314 (18.2) | 117 (14.2) | .73 (.58–.92) | .009 | 13 (10.1) | 0.46 (.25–.83) | .010 | 0.70 (.58–.85) | <.001 |
Abbreviation: CI, confidence interval; OR, odds ratio.
Hospitalization for last bloodstream infection is used. All analyses are logistic regression, except for ordered logistic regression for sepsis categories, and are adjusted for age at first Nord-Trøndelag Health Study participation, sex, and the 5 first principal components. The analyses compare genotype group to TT or the effect of each additional C allele (using dosages). Severe sepsis was defined as sepsis with additional diagnosis code of organ dysfunction or the use of diagnosis codes for severe sepsis.