Table 2.
Observed and Predicted Cure Rates and Egg Reduction Rates Against Hookworm of Adults at 3 Weeks Follow-up
| Result | Placebo | Albendazole, 200 mg | Albendazole, 400 mg | Albendazole, 600 mg | Albendazole, 800 mg |
|---|---|---|---|---|---|
| Positive before treatment | 35 | 35 | 30 | 39 | 34 |
| Cured after treatment | 5 | 16 | 16 | 22 | 32 |
| Observed CR (95% CI) | 14.3 (4.8 to 30.3) | 45.7 (28.8 to 63.4) | 53.3 (34.3 to 71.7) | 56.4 (39.6 to 72.2) | 94.1 (80.3 to 99.3) |
| Predicted CR (95% CI) | 16.8 (7.4 to 33.8) | 37.9 (26.2 to 51.3) | 55.6 (44.7 to 66.0) | 67.3 (55.6 to 77.2) | 74.9 (55.6 to 87.7) |
| EPG geometric mean | |||||
| Baseline | 135.9 | 132.3 | 118.6 | 204.1 | 139.6 |
| 3 weeks follow-up | 91.1 | 8.2 | 5.0 | 6.2 | 0.2 |
| Observed ERR (95% CI) | 33.0 (−27.1 to 67.3) | 93.8 (87.0 to 97.3) | 95.8 (90.2 to 98.3) | 97.0 (92.5 to 98.9) | 99.8 (99.5 to 100.0) |
| Predicted ERR (95% CI) | 33.0 (19.6 to 49.9) | 93.5 (79.1 to 98.2) | 96.4 (90.4 to 98.7) | 97.1 (88.4 to 99.3) | 97.5 (86.0 to 99.6) |
| EPG arithmetic mean | |||||
| Baseline | 348.3 | 325.0 | 242.0 | 414.9 | 275.6 |
| 3 weeks follow-up | 478.6 | 63.9 | 32.2 | 69.5 | 2.1 |
| Observed ERR (95% CI) | −37.4 (−137.1 to 44.6) | 80.3 (58.1 to 91.8) | 86.7 (75.3 to 94.0) | 83.3 (68.0 to 92.7) | 99.2 (97.6 to 100.0) |
Abbreviations: CI, confidence interval; CR, cure rate; EPG, eggs per gram; ERR, egg reduction rate.