Table 2.
Hazard ratio (HR) and 95% confidence interval (95%CI) for the criteria for COVID-19-related hospitalization and in-hospital death (Note: some associations were not estimated due to insufficient sample sizes).
| Hospitalization with COVID-19 |
In-hospital death with COVID-19 |
|||||
|---|---|---|---|---|---|---|
| Number of events | Age-sex adj | Fully adj | Number of events | Age-sex adj | Fully adj | |
| Characteristics sociodemographic | ||||||
| Age - no (%) | ||||||
| < 5 | 161 | 0·07 (0·06 - 0·08) | 0·07 (0·06 - 0·08) | 1 | 0·02 (0 - 0·17) | 0·03 (0 - 0·19) |
| 5 - 9 | 115 | 0·04 (0·03 - 0·04) | 0·04 (0·03 - 0·05) | 1 | 0·02 (0 - 0·13) | 0·02 (0 - 0·14) |
| 10 - 14 | 133 | 0·04 (0·03 - 0·05) | 0·05 (0·04 - 0·05) | |||
| 15 - 19 | 393 | 0·13 (0·11 - 0·14) | 0·14 (0·13 - 0·16) | 2 | 0·04 (0·01 - 0·15) | 0·04 (0·01 - 0·17) |
| 20 - 24 | 1,123 | 0·39 (0·37 - 0·42) | 0·43 (0·4 - 0·46) | 3 | 0·06 (0·02 - 0·19) | 0·07 (0·02 - 0·21) |
| 25 - 29 | 1,772 | 0·6 (0·57 - 0·64) | 0·62 (0·59 - 0·66) | 7 | 0·14 (0·06 - 0·3) | 0·14 (0·06 - 0·31) |
| 30 - 34 | 2,285 | 0·71 (0·67 - 0·75) | 0·72 (0·68 - 0·76) | 19 | 0·34 (0·2 - 0·57) | 0·34 (0·21 - 0·58) |
| 35 - 39 | 2,780 | 0·84 (0·8 - 0·88) | 0·85 (0·81 - 0·9) | 45 | 0·78 (0·52 - 1·15) | 0·79 (0·53 - 1·17) |
| 40 - 44 | 3,252 | 1 | 1 | 57 | 1 | 1 |
| 45 - 49 | 4,554 | 1·3 (1·24 - 1·36) | 1·28 (1·22 - 1·34) | 100 | 1·63 (1·18 - 2·25) | 1·58 (1·14 - 2·19) |
| 50 - 54 | 5,746 | 1·64 (1·57 - 1·72) | 1·56 (1·49 - 1·62) | 273 | 4·44 (3·34 - 5·91) | 4·14 (3·11 - 5·51) |
| 55 - 59 | 6,705 | 1·94 (1·86 - 2·03) | 1·74 (1·67 - 1·82) | 417 | 6·88 (5·22 - 9·08) | 6·03 (4·57 - 7·95) |
| 60 - 64 | 7,381 | 2·29 (2·2 - 2·39) | 1·97 (1·89 - 2·05) | 711 | 12·6 (9·62 - 16·51) | 10·54 (8·04 - 13·81) |
| 65 - 69 | 7,478 | 2·47 (2·38 - 2·58) | 2·03 (1·95 - 2·12) | 1,119 | 21·15 (16·21 - 27·6) | 17·03 (13·04 - 22·24) |
| 70 - 74 | 8,662 | 2·99 (2·88 - 3·12) | 2·32 (2·22 - 2·42) | 1,655 | 32·77 (25·16 - 42·67) | 24·95 (19·13 - 32·53) |
| 75 - 79 | 7,548 | 4·21 (4·04 - 4·39) | 2·94 (2·82 - 3·07) | 1,795 | 57·64 (44·28 - 75·03) | 39·69 (30·44 - 51·76) |
| 80 - 84 | 8,727 | 6·01 (5·77 - 6·25) | 3·78 (3·63 - 3·95) | 2,657 | 106·43 (81·87 - 138·36) | 65·34 (50·16 - 85·11) |
| 85 - 89 | 9,562 | 8·82 (8·48 - 9·18) | 5·01 (4·8 - 5·23) | 3,303 | 181·69 (139·84 - 236·08) | 100·28 (77 - 130·61) |
| 90 - 110 | 9,432 | 12·21 (11·73 - 12·71) | 6·44 (6·16 - 6·72) | 3,496 | 280·42 (215·83 - 364·34) | 144·06 (110·59 - 187·65) |
| Male sex - no (%) | 46,766 | 1·46 (1·44 - 1·48) | 1·38 (1·36 - 1·4) | 9,359 | 2·26 (2·19 - 2·34) | 2·08 (2·01 - 2·16) |
| Regions - no (%) | ||||||
| Ile de France | 30,009 | 1 | 1 | 5,612 | 1 | 1 |
| Grand Est | 12,939 | 0·81 (0·79 - 0·83) | 0·7 (0·68 - 0·71) | 2,894 | 0·88 (0·84 - 0·92) | 0·74 (0·7 - 0·78) |
| Hauts-de-France | 8,852 | 0·55 (0·54 - 0·57) | 0·45 (0·44 - 0·46) | 1,729 | 0·55 (0·52 - 0·58) | 0·45 (0·43 - 0·48) |
| Auvergne-Rhône-Alpes | 8,535 | 0·37 (0·36 - 0·38) | 0·35 (0·34 - 0·35) | 1,499 | 0·31 (0·29 - 0·33) | 0·28 (0·27 - 0·3) |
| Bourgogne-Franche-Comté | 4,303 | 0·49 (0·48 - 0·51) | 0·43 (0·42 - 0·45) | 872 | 0·45 (0·42 - 0·48) | 0·39 (0·36 - 0·42) |
| Centre-Val-de-Loire | 2,264 | 0·28 (0·27 - 0·29) | 0·26 (0·24 - 0·27) | 408 | 0·23 (0·21 - 0·25) | 0·21 (0·19 - 0·23) |
| Provence-Alpes-Côte d'Azur | 7,971 | 0·48 (0·47 - 0·49) | 0·46 (0·45 - 0·47) | 772 | 0·22 (0·2 - 0·23) | 0·2 (0·18 - 0·21) |
| Occitanie | 3,161 | 0·17 (0·16 - 0·17) | 0·15 (0·15 - 0·16) | 444 | 0·11 (0·1 - 0·12) | 0·1 (0·09 - 0·11) |
| Nouvelle-Aquitaine | 2,724 | 0·14 (0·13 - 0·14) | 0·13 (0·12 - 0·13) | 388 | 0·09 (0·08 - 0·1) | 0·08 (0·07 - 0·09) |
| Normandie | 2,455 | 0·25 (0·24 - 0·26) | 0·21 (0·2 - 0·22) | 379 | 0·18 (0·16 - 0·2) | 0·15 (0·14 - 0·17) |
| Pays de la Loire | 2,319 | 0·21 (0·2 - 0·21) | 0·19 (0·19 - 0·2) | 359 | 0·15 (0·13 - 0·17) | 0·14 (0·13 - 0·16) |
| Bretagne | 1,289 | 0·12 (0·12 - 0·13) | 0·12 (0·11 - 0·13) | 212 | 0·1 (0·08 - 0·11) | 0·09 (0·08 - 0·1) |
| Corse | 193 | 0·24 (0·21 - 0·27) | 0·22 (0·19 - 0·25) | 27 | 0·15 (0·1 - 0·22) | 0·13 (0·09 - 0·2) |
| Guadeloupe | 122 | 0·11 (0·09 - 0·13) | 0·11 (0·09 - 0·13) | 23 | 0·11 (0·07 - 0·16) | 0·11 (0·07 - 0·17) |
| Martinique | 148 | 0·14 (0·12 - 0·16) | 0·14 (0·12 - 0·17) | 16 | 0·07 (0·04 - 0·12) | 0·08 (0·05 - 0·13) |
| Guyane | 168 | 0·55 (0·47 - 0·64) | 0·56 (0·48 - 0·66) | 8 | 0·2 (0·1 - 0·4) | 0·22 (0·11 - 0·44) |
| La Réunion | 157 | 0·08 (0·07 - 0·1) | 0·08 (0·07 - 0·09) | 3 | 0·01 (0 - 0·03) | 0·01 (0 - 0·03) |
| Mayotte | 161 | 1·14 (0·98 - 1·33) | 1·24 (1·05 - 1·47) | 13 | 0·82 (0·48 - 1·42) | 1·06 (0·61 - 1·86) |
| Unknown | 39 | 0·2 (0·14 - 0·27) | 0·21 (0·15 - 0·29) | 3 | 0·07 (0·02 - 0·23) | 0·08 (0·03 - 0·25) |
| Social deprivation index (quintiles) - no (%) | ||||||
| 1 (the least deprivation) | 20,893 | 1 | 1 | 3,847 | 1 | 1 |
| 2 | 14,699 | 0·71 (0·69 - 0·72) | 1·09 (1·06 - 1·11) | 2,536 | 0·66 (0·63 - 0·69) | 1·12 (1·06 - 1·18) |
| 3 | 14,375 | 0·65 (0·64 - 0·67) | 1·15 (1·12 - 1·17) | 2,451 | 0·57 (0·54 - 0·6) | 1·2 (1·13 - 1·27) |
| 4 | 15,117 | 0·68 (0·66 - 0·69) | 1·22 (1·19 - 1·25) | 2,814 | 0·63 (0·6 - 0·66) | 1·25 (1·19 - 1·32) |
| 5 (the most deprivation) | 20,860 | 0·97 (0·95 - 0·99) | 1·45 (1·42 - 1·48) | 3,734 | 0·86 (0·82 - 0·9) | 1·38 (1·31 - 1·45) |
| Unknown | 1,865 | 0·42 (0·4 - 0·44) | 1·07 (1·01 - 1·14) | 279 | 0·33 (0·29 - 0·37) | 1·08 (0·94 - 1·24) |
| Lifestyle habits | ||||||
| Smoking | 3,995 | 1·2 (1·16 - 1·24) | 0·86 (0·84 - 0·89) | 799 | 1·88 (1·75 - 2·02) | 1·1 (1·01 - 1·18) |
| Alcoholism | 1,768 | 1·61 (1·54 - 1·69) | 1·18 (1·12 - 1·24) | 319 | 2·21 (1·98 - 2·48) | 1·36 (1·21 - 1·52) |
| Opioid addiction | 308 | 1·42 (1·27 - 1·59) | 1·11 (0·99 - 1·25) | 18 | 1·74 (1·09 - 2·77) | 1·05 (0·66 - 1·67) |
| Comorbidities | ||||||
| Cardiometabolic | ||||||
| Obesity | 2,461 | 2·37 (2·28 - 2·47) | 1·63 (1·57 - 1·7) | 296 | 2·55 (2·27 - 2·86) | 1·56 (1·39 - 1·76) |
| Diabetes | 19,231 | 2·03 (2 - 2·07) | 1·64 (1·61 - 1·67) | 4,798 | 2·14 (2·07 - 2·21) | 1·75 (1·68 - 1·81) |
| Dyslipidemia and lipid-lowering treatments | 23,617 | 1·22 (1·2 - 1·24) | 0·89 (0·87 - 0·9) | 5,679 | 1·15 (1·11 - 1·19) | 0·84 (0·81 - 0·88) |
| Hereditary metabolic diseases or amyloidosis | 317 | 1·38 (1·23 - 1·54) | 1·11 (0·99 - 1·24) | 82 | 1·64 (1·32 - 2·03) | 1·24 (1 - 1·54) |
| Hypertension | 43,544 | 1·46 (1·44 - 1·48) | 1·17 (1·15 - 1·19) | 10,716 | 1·44 (1·39 - 1·49) | 1·15 (1·1 - 1·19) |
| Coronary diseases | 10,678 | 1·57 (1·54 - 1·6) | 1·14 (1·12 - 1·17) | 3,124 | 1·61 (1·55 - 1·68) | 1·16 (1·11 - 1·21) |
| Obliterating arterial disease of the lower limb | 4,231 | 1·77 (1·72 - 1·83) | 1·26 (1·22 - 1·3) | 1,395 | 2·02 (1·91 - 2·13) | 1·41 (1·33 - 1·5) |
| Cardiac rhythm or conduction disturbances | 16,254 | 1·97 (1·94 - 2·01) | 1·37 (1·34 - 1·4) | 5,210 | 2·16 (2·08 - 2·24) | 1·41 (1·35 - 1·46) |
| Heart failure | 7,578 | 2·54 (2·48 - 2·6) | 1·44 (1·4 - 1·48) | 2,613 | 2·8 (2·68 - 2·92) | 1·54 (1·47 - 1·62) |
| Valvular diseases | 4,802 | 1·8 (1·74 - 1·85) | 1·15 (1·11 - 1·19) | 1,593 | 1·95 (1·85 - 2·06) | 1·2 (1·14 - 1·27) |
| Stroke | 5,626 | 1·83 (1·78 - 1·88) | 1·33 (1·29 - 1·37) | 1,748 | 1·98 (1·88 - 2·08) | 1·39 (1·32 - 1·47) |
| Respiratory | ||||||
| Chronic respiratory diseases (excluding cystic fibrosis) | 12,789 | 1·92 (1·88 - 1·96) | 1·56 (1·53 - 1·59) | 3,064 | 1·98 (1·9 - 2·06) | 1·48 (1·42 - 1·55) |
| Cystic fibrosis | 32 | 6·19 (4·37 - 8·75) | 3·74 (2·62 - 5·34) | 6 | ||
| Pulmonary embolism | 1,065 | 2·13 (2 - 2·26) | 1·44 (1·35 - 1·53) | 309 | 2·29 (2·05 - 2·56) | 1·45 (1·3 - 1·63) |
| Cancer | ||||||
| Female breast cancer (active) | 630 | 1·49 (1·38 - 1·62) | 1·41 (1·3 - 1·52) | 142 | 1·99 (1·69 - 2·36) | 1·8 (1·52 - 2·12) |
| Female breast cancer (under surveillance) | 1,250 | 1·04 (0·98 - 1·1) | 0·97 (0·92 - 1·02) | 284 | 1·22 (1·08 - 1·37) | 1·1 (0·97 - 1·23) |
| Colorectal cancer (active) | 615 | 1·55 (1·43 - 1·67) | 1·36 (1·25 - 1·47) | 167 | 1·63 (1·4 - 1·9) | 1·4 (1·2 - 1·63) |
| Colorectal cancer (under surveillance) | 898 | 1·13 (1·06 - 1·21) | 1·04 (0·97 - 1·11) | 250 | 1·09 (0·96 - 1·24) | 0,98 (0,86 - 1,11) |
| Lung cancer (active) | 621 | 3·6 (3·33 - 3·9) | 2·6 (2·4 - 2·81) | 223 | 5·7 (4·99 - 6·5) | 4 (3,5 - 4,57) |
| Lung cancer (under surveillance) | 301 | 1·97 (1·76 - 2·21) | 1·37 (1·22 - 1·53) | 100 | 2·56 (2·1 - 3·12) | 1,7 (1,4 - 2,07) |
| Prostate cancer (active) | 1,029 | 1·21 (1·13 - 1·28) | 1·19 (1·12 - 1·27) | 337 | 1·21 (1·08 - 1·35) | 1,2 (1,08 - 1,34) |
| Prostate cancer (under surveillance) | 1,424 | 1·05 (1 - 1·11) | 1·01 (0·96 - 1·07) | 445 | 0·96 (0·87 - 1·05) | 0,92 (0,83 - 1,01) |
| Other cancers (active) | 3,944 | 1·82 (1·76 - 1·88) | 1·65 (1·59 - 1·7) | 1,240 | 2·14 (2·01 - 2·26) | 1,95 (1,84 - 2,07) |
| Other cancers (under surveillance) | 3,451 | 1·23 (1·19 - 1·27) | 1·14 (1·1 - 1·18) | 963 | 1·25 (1·17 - 1·33) | 1,18 (1,1 - 1,26) |
| Inflammatory and skin diseases | ||||||
| Chronic inflammatory bowel diseases | 600 | 1·48 (1·37 - 1·61) | 1·28 (1·18 - 1·38) | 78 | 1·23 (0·99 - 1·54) | 0,98 (0,78 - 1,22) |
| Rheumatoid arthritis and related diseases | 1,172 | 1·6 (1·51 - 1·7) | 1·48 (1·39 - 1·56) | 268 | 1·64 (1·45 - 1·85) | 1,53 (1,35 - 1,72) |
| Ankylosing spondylitis and related diseases | 569 | 1·48 (1·36 - 1·6) | 1·25 (1·15 - 1·35) | 90 | 1·41 (1·15 - 1·74) | 1,13 (0,91 - 1,39) |
| Psoriasis | 787 | 1·3 (1·21 - 1·39) | 1·12 (1·04 - 1·2) | 142 | 1·17 (0·99 - 1·38) | 1 (0,85 - 1,18) |
| Psychological and neurodegenerative diseases | ||||||
| Neurotic and Mood Disorders, use of antidepressant treatments | 14,574 | 1·6 (1·57 - 1·63) | 1·31 (1·28 - 1·33) | 3,402 | 1·8 (1·73 - 1·87) | 1,36 (1,3 - 1,41) |
| Psychotics disorders, use of neuroleptics treatments | 3,384 | 2·18 (2·11 - 2·26) | 1·61 (1·56 - 1·67) | 940 | 3·03 (2·83 - 3·23) | 2,13 (1,99 - 2,28) |
| Psychiatric disorders starting in childhood | 146 | 3·31 (2·82 - 3·9) | 2·05 (1·74 - 2·41) | 25 | 7·68 (5·19 - 11·38) | 3,31 (2,23 - 4,93) |
| Down syndrom | 208 | 8·93 (7·79 - 10·23) | 7·03 (6·13 - 8·07) | 48 | 40·39 (30·37 - 53·71) | 22,87 (17,04 - 30,69) |
| Epilepsy | 1,302 | 2·29 (2·16 - 2·41) | 1·52 (1·44 - 1·61) | 292 | 2·37 (2·11 - 2·66) | 1,44 (1,28 - 1,62) |
| Multiple sclerosis | 324 | 2·11 (1·89 - 2·35) | 1·74 (1·55 - 1·94) | 58 | 3·39 (2·62 - 4·39) | 2,63 (2,02 - 3,42) |
| Paraplegia | 463 | 2·77 (2·52 - 3·03) | 1·95 (1·78 - 2·15) | 103 | 3·34 (2·75 - 4·05) | 2,23 (1,83 - 2,73) |
| Myopathy or myasthenia gravis | 153 | 1·83 (1·56 - 2·15) | 1·37 (1·17 - 1·61) | 41 | 2·47 (1·82 - 3·36) | 1,88 (1,38 - 2,55) |
| Parkinson disease | 1,934 | 1·88 (1·79 - 1·97) | 1·52 (1·45 - 1·59) | 645 | 2·04 (1·88 - 2·2) | 1,63 (1,5 - 1,76) |
| Dementias (including Alzheimer's disease) | 7,850 | 2·66 (2·6 - 2·73) | 2·04 (1·99 - 2·1) | 2,819 | 3·06 (2·93 - 3·2) | 2,16 (2,06 - 2,26) |
| Mental impairment | 583 | 4·25 (3·92 - 4·61) | 3·83 (3·52 - 4·16) | 120 | 7·98 (6·67 - 9·56) | 7,31 (6,05 - 8,82) |
| Other pathologies | ||||||
| Hemophilia or severe hemostasis disorders | 167 | 1·74 (1·49 - 2·03) | 1·47 (1·26 - 1·71) | 39 | 1·96 (1·43 - 2·69) | 1,66 (1,22 - 2,28) |
| HIV infection | 575 | 2·74 (2·53 - 2·98) | 1·88 (1·73 - 2·04) | 64 | 2·7 (2·11 - 3·46) | 1,93 (1,51 - 2,47) |
| Liver diseases | 2,170 | 2·65 (2·54 - 2·77) | 1·5 (1·43 - 1·57) | 487 | 3·16 (2·89 - 3·46) | 1,57 (1,42 - 1,72) |
| Chronic dialysis | 1,099 | 7·3 (6·88 - 7·75) | 4·16 (3·92 - 4·42) | 342 | 7·92 (7·11 - 8·82) | 4,65 (4,17 - 5,19) |
| Renal transplant | 547 | 7·18 (6·61 - 7·81) | 4·55 (4·18 - 4·95) | 137 | 11·29 (9·53 - 13·36) | 7,09 (5,98 - 8,42) |
| Cardiac transplant | 22 | 9·28 (6·12 - 14·08) | 2·15 (1·41 - 3·27) | 4 | 17·1 (6·41 - 45·58) | 2,63 (0,98 - 7,04) |
| Liver transplant | 27 | 3·25 (2·23 - 4·74) | 0·84 (0·58 - 1·23) | 4 | 3·92 (1·47 - 10·46) | 0,72 (0,27 - 1,94) |
| Lung transplant | 25 | 14·3 (9·7 - 21·08) | 3·53 (2·35 - 5·29) | 6 | 19·14 (8·53 - 42·97) | 7,04 (3,15 - 15,73) |