Table 3.
Hazard ratio (HR) and 95% Confidence Interval (95%CI) for the criteria for COVID-19-related hospitalization and in-hospital mortality: stratification for people 80 years and older vs. other people on adjusted analysis (Note: some associations were not estimated due to insufficient sample sizes; models were adjusted for age as a categorical variable).
| Hospitalization with COVID-19 |
In-hospital death with COVID-19 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| < 80 years |
80 years nd older |
< 80 years |
80 years and older |
|||||||
| Sample size | Number of events | HR | Sample size | Number of events | HR | Number of events | HR | Number of events | HR | |
| Characteristics sociodemographic | ||||||||||
| Male sex - no (%) | 30,065,855 | 34,299 | 1·36 (1·34 - 1·38) | 1,655,925 | 12,467 | 1·41 (1·37 - 1·45) | 4,345 | 2·25 (2·12 - 2·39) | 5,014 | 2·01 (1·92 - 2·1) |
| Regions - no (%) | ||||||||||
| Ile de France | 11,391,095 | 21,613 | 1 | 588,058 | 8,396 | 1 | 2,626 | 1 | 2,986 | 1 |
| Grand Est | 5,034,098 | 8,369 | 0·65 (0·63 - 0·67) | 365,080 | 4,570 | 0·85 (0·82 - 0·89) | 1,159 | 0·58 (0·54 - 0·62) | 1,735 | 0·92 (0·86 - 0·99) |
| Hauts-de-France | 5,547,664 | 5,888 | 0·41 (0·4 - 0·42) | 341,508 | 2,964 | 0·59 (0·56 - 0·62) | 661 | 0·31 (0·28 - 0·34) | 1,068 | 0·61 (0·56 - 0·66) |
| Auvergne-Rhône-Alpes | 7,400,076 | 5,072 | 0·31 (0·3 - 0·32) | 530,463 | 3,463 | 0·44 (0·42 - 0·46) | 473 | 0·19 (0·18 - 0·21) | 1,026 | 0·37 (0·34 - 0·4) |
| Bourgogne-Franche-Comté | 2,500,374 | 2,613 | 0·4 (0·38 - 0·42) | 215,438 | 1,690 | 0·53 (0·51 - 0·56) | 266 | 0·25 (0·22 - 0·29) | 606 | 0·54 (0·5 - 0·6) |
| Centre-Val-de-Loire | 2,336,449 | 1,375 | 0·24 (0·22 - 0·25) | 196,744 | 889 | 0·32 (0·29 - 0·34) | 120 | 0·13 (0·11 - 0·16) | 288 | 0·29 (0·26 - 0·33) |
| Provence-Alpes-Côte d'Azur | 4,813,164 | 6,355 | 0·56 (0·54 - 0·58) | 398,311 | 1,616 | 0·28 (0·26 - 0·29) | 263 | 0·15 (0·13 - 0·17) | 509 | 0·25 (0·23 - 0·27) |
| Occitanie | 5,458,331 | 2,192 | 0·17 (0·16 - 0·17) | 450,075 | 969 | 0·14 (0·13 - 0·15) | 152 | 0·07 (0·06 - 0·09) | 292 | 0·12 (0·11 - 0·14) |
| Nouvelle-Aquitaine | 5,462,379 | 1,803 | 0·13 (0·13 - 0·14) | 488,706 | 921 | 0·13 (0·12 - 0·14) | 122 | 0·06 (0·05 - 0·07) | 266 | 0·1 (0·09 - 0·12) |
| Normandie | 3,009,313 | 1,718 | 0·22 (0·21 - 0·23) | 234,572 | 737 | 0·21 (0·2 - 0·23) | 155 | 0·13 (0·11 - 0·15) | 224 | 0·18 (0·16 - 0·21) |
| Pays de la Loire | 3,500,482 | 1,448 | 0·18 (0·17 - 0·19) | 266,835 | 871 | 0·23 (0·21 - 0·25) | 103 | 0·09 (0·07 - 0·11) | 256 | 0·19 (0·17 - 0·22) |
| Bretagne | 3,050,605 | 807 | 0·12 (0·11 - 0·12) | 251,951 | 482 | 0·13 (0·12 - 0·15) | 62 | 0·06 (0·05 - 0·08) | 150 | 0·12 (0·1 - 0·14) |
| Corse | 229,184 | 139 | 0·23 (0·2 - 0·28) | 19,071 | 54 | 0·2 (0·15 - 0·26) | 10 | 0·11 (0·06 - 0·2) | 17 | 0·17 (0·11 - 0·28) |
| Guadeloupe | 353,603 | 96 | 0·12 (0·1 - 0·15) | 22,067 | 26 | 0·09 (0·06 - 0·13) | 13 | 0·12 (0·07 - 0·22) | 10 | 0·1 (0·05 - 0·19) |
| Martinique | 326,972 | 119 | 0·16 (0·13 - 0·2) | 24,020 | 29 | 0·1 (0·07 - 0·14) | 6 | 0·06 (0·03 - 0·14) | 10 | 0·1 (0·05 - 0·18) |
| Guyane | 187,765 | 154 | 0·58 (0·49 - 0·69) | 2,955 | 14 | 0·41 (0·24 - 0·7) | 3 | 0·11 (0·03 - 0·34) | 5 | 0·43 (0·18 - 1·06) |
| La Réunion | 850,247 | 149 | 0·09 (0·08 - 0·11) | 26,623 | 8 | 0·02 (0·01 - 0·04) | 2 | 0·01 (0 - 0·04) | 1 | 0·01 (0 - 0·06) |
| Mayotte | 100,381 | 146 | 1·21 (1·01 - 1·44) | 1,132 | 15 | 1·43 (0·85 - 2·39) | 9 | 0·9 (0·45 - 1·82) | 4 | 1·15 (0·42 - 3·1) |
| Unknown | 70,750 | 32 | 0·25 (0·17 - 0·35) | 4,049 | 7 | 0·13 (0·06 - 0·27) | 0 | 3 | 0·16 (0·05 - 0·49) | |
| Social deprivation index (quintiles) - no (%) | ||||||||||
| 1 (the least deprivation) | 12,188,387 | 13,762 | 1 | 761,883 | 7,131 | 1 | 1,359 | 1 | 2,488 | 1 |
| 2 | 12,005,297 | 10,291 | 1·14 (1·11 - 1·17) | 763,359 | 4,408 | 0·97 (0·93 - 1·01) | 1,027 | 1·35 (1·24 - 1·46) | 1,509 | 0·97 (0·9 - 1·03) |
| 3 | 11,805,221 | 9,837 | 1·2 (1·17 - 1·24) | 885,767 | 4,538 | 1·01 (0·97 - 1·05) | 966 | 1·55 (1·41 - 1·69) | 1,485 | 0·98 (0·91 - 1·05) |
| 4 | 11,565,049 | 10,006 | 1·29 (1·26 - 1·33) | 933,160 | 5,111 | 1·03 (0·99 - 1·08) | 1,094 | 1·61 (1·48 - 1·76) | 1,720 | 1·02 (0·95 - 1·09) |
| 5 (the most deprivation) | 11,355,163 | 14,862 | 1·64 (1·6 - 1·69) | 922,159 | 5,998 | 1·04 (1 - 1·08) | 1,664 | 1·99 (1·84 - 2·16) | 2,070 | 1·02 (0·95 - 1·09) |
| Unknown | 2,703,815 | 1,330 | 1·11 (1·03 - 1·21) | 161,330 | 535 | 0·97 (0·88 - 1·07) | 95 | 1·29 (1 - 1·66) | 184 | 0·94 (0·8 - 1·11) |
| Lifestyle habits | ||||||||||
| Smoking | 2,278,613 | 3,078 | 0·78 (0·75 - 0·81) | 70,956 | 917 | 1·26 (1·17 - 1·35) | 472 | 0·96 (0·87 - 1·07) | 327 | 1·18 (1·05 - 1·33) |
| Alcoholism | 679,184 | 1,544 | 1·14 (1·08 - 1·2) | 20,266 | 224 | 1·26 (1·1 - 1·44) | 241 | 1·23 (1·07 - 1·42) | 78 | 1·2 (0·95 - 1·5) |
| Opioide addiction | 207,516 | 298 | 1·09 (0·97 - 1·22) | 593 | 10 | 1·86 (1 - 3·45) | 14 | 0·82 (0·48 - 1·39) | 4 | 2·23 (0·84 - 5·94) |
| Comorbidities | ||||||||||
| Cardiometabolic | ||||||||||
| Obesity | 853,075 | 2,202 | 1·58 (1·52 - 1·65) | 22,310 | 259 | 1·52 (1·35 - 1·72) | 214 | 1·46 (1·27 - 1·68) | 82 | 1·48 (1·19 - 1·84) |
| Diabetes | 3,020,096 | 12,419 | 1·81 (1·77 - 1·85) | 786,059 | 6,812 | 1·39 (1·35 - 1·43) | 2,312 | 2·11 (1·99 - 2·24) | 2,486 | 1·49 (1·42 - 1·56) |
| Dyslipidemia and lipid-lowering treatments | 5,169,559 | 14,127 | 0·88 (0·86 - 0·9) | 1,541,826 | 9,490 | 0·88 (0·85 - 0·9) | 2,485 | 0·86 (0·81 - 0·91) | 3,194 | 0·81 (0·77 - 0·85) |
| Hereditary metabolic diseases or amyloidosis | 99,810 | 200 | 1·09 (0·94 - 1·25) | 13,892 | 117 | 1·12 (0·93 - 1·34) | 35 | 1·17 (0·84 - 1·64) | 47 | 1·26 (0·95 - 1·68) |
| Hypertension | 8,848,157 | 23,479 | 1·25 (1·23 - 1·28) | 3,094,350 | 20,065 | 0·99 (0·96 - 1·02) | 3,809 | 1·28 (1·21 - 1·36) | 6,907 | 1·01 (0·97 - 1·07) |
| Coronary diseases | 1,337,250 | 5,204 | 1·17 (1·13 - 1·21) | 617,683 | 5,474 | 1·13 (1·1 - 1·17) | 1,080 | 1·14 (1·06 - 1·23) | 2,044 | 1·16 (1·1 - 1·23) |
| Obliterating arterial disease of the lower limb | 427,503 | 1,970 | 1·2 (1·15 - 1·26) | 216,250 | 2,261 | 1·31 (1·25 - 1·37) | 523 | 1·41 (1·28 - 1·55) | 872 | 1·38 (1·29 - 1·49) |
| Cardiac rhythm or conduction disturbances | 1,200,780 | 5,451 | 1·36 (1·32 - 1·41) | 1,073,211 | 10,803 | 1·37 (1·34 - 1·41) | 1,256 | 1·43 (1·33 - 1·55) | 3,954 | 1·4 (1·34 - 1·47) |
| Heart failure | 303,886 | 2,336 | 1·45 (1·38 - 1·52) | 391,092 | 5,242 | 1·48 (1·43 - 1·53) | 661 | 1·89 (1·71 - 2·08) | 1,952 | 1·5 (1·42 - 1·59) |
| Valvular diseases | 338,688 | 1,536 | 1·1 (1·04 - 1·17) | 306,792 | 3,266 | 1·17 (1·13 - 1·22) | 371 | 1·14 (1·02 - 1·28) | 1,222 | 1·22 (1·15 - 1·31) |
| Stroke | 537,146 | 2,356 | 1·4 (1·35 - 1·47) | 318,505 | 3,270 | 1·27 (1·22 - 1·32) | 539 | 1·54 (1·4 - 1·69) | 1,209 | 1·32 (1·24 - 1·4) |
| Respiratory | ||||||||||
| Chronic respiratory diseases (excluding cystic fibrosis) | 6,011,758 | 15,522 | 1·68 (1·64 - 1·72) | 1,033,712 | 10,056 | 1·35 (1·3 - 1·39) | 2,500 | 1·64 (1·54 - 1·76) | 3,628 | 1·38 (1·3 - 1·46) |
| Cystic fibrosis | 8,441 | 28 | 3·73 (2·54 - 5·46) | 143 | 4 | 3·27 (1·23 - 8·7) | 4 | 2 | ||
| Pulmonary embolism | 98,968 | 479 | 1·57 (1·44 - 1·72) | 50,063 | 586 | 1·33 (1·22 - 1·44) | 101 | 1·7 (1·39 - 2·07) | 208 | 1·35 (1·17 - 1·55) |
| Cancer | ||||||||||
| Female breast cancer (active) | 181,015 | 446 | 1·57 (1·43 - 1·72) | 30,485 | 184 | 1·12 (0·97 - 1·3) | 93 | 3·3 (2·68 - 4·07) | 49 | 1·01 (0·76 - 1·34) |
| Female breast cancer (under surveillance) | 364,727 | 560 | 0·9 (0·82 - 0·97) | 112,633 | 690 | 1·04 (0·96 - 1·12) | 75 | 1·11 (0·88 - 1·4) | 209 | 1·09 (0·95 - 1·26) |
| Colorectal cancer (active) | 96,847 | 386 | 1·55 (1·4 - 1·71) | 30,905 | 229 | 1·11 (0·97 - 1·26) | 96 | 2·01 (1·64 - 2·46) | 71 | 0·97 (0·77 - 1·22) |
| Colorectal cancer (under surveillance) | 133,880 | 352 | 1·04 (0·93 - 1·15) | 74,096 | 546 | 1·03 (0·95 - 1·12) | 63 | 0·98 (0·76 - 1·25) | 187 | 0·99 (0·85 - 1·14) |
| Lung cancer (active) | 57,656 | 488 | 2·78 (2·54 - 3·04) | 9,129 | 133 | 1·96 (1·65 - 2·32) | 170 | 5·03 (4·3 - 5·89) | 53 | 2·21 (1·68 - 2·9) |
| Lung cancer (under surveillance) | 39,321 | 191 | 1·44 (1·25 - 1·66) | 10,078 | 110 | 1·23 (1·02 - 1·49) | 45 | 1·69 (1·26 - 2·27) | 55 | 1·69 (1·3 - 2·21) |
| Prostate cancer (active) | 141,643 | 491 | 1·22 (1·12 - 1·34) | 60,623 | 538 | 1·16 (1·07 - 1·27) | 111 | 1·25 (1·03 - 1·51) | 226 | 1·2 (1·05 - 1·37) |
| Prostate cancer (under surveillance) | 190,629 | 567 | 0·99 (0·91 - 1·07) | 107,243 | 857 | 1·03 (0·96 - 1·1) | 125 | 0·92 (0·77 - 1·1) | 320 | 0·95 (0·84 - 1·06) |
| Other cancers (active) | 529,287 | 2,335 | 1·96 (1·88 - 2·04) | 183,835 | 1,609 | 1·33 (1·26 - 1·4) | 619 | 2·99 (2·74 - 3·26) | 621 | 1·44 (1·32 - 1·56) |
| Other cancers (under surveillance) | 641,791 | 1,593 | 1·17 (1·11 - 1·23) | 243,807 | 1,858 | 1·1 (1·05 - 1·16) | 290 | 1·25 (1·11 - 1·41) | 673 | 1·13 (1·04 - 1·22) |
| Inflammatoy and skin diseases | ||||||||||
| Chronic inflammatory bowel diseases | 253,396 | 453 | 1·27 (1·15 - 1·39) | 14,789 | 147 | 1·32 (1·12 - 1·55) | 38 | 0·91 (0·66 - 1·26) | 40 | 1·03 (0·76 - 1·41) |
| Rheumatoid arthritis and related diseases | 227,136 | 661 | 1·55 (1·43 - 1·67) | 60,617 | 511 | 1·39 (1·27 - 1·51) | 105 | 1·83 (1·51 - 2·23) | 163 | 1·36 (1·17 - 1·59) |
| Ankylosing spondylitis and related diseases | 207,427 | 431 | 1·22 (1·11 - 1·34) | 14,640 | 138 | 1·28 (1·08 - 1·51) | 48 | 1·13 (0·85 - 1·51) | 42 | 1·09 (0·81 - 1·48) |
| Psoriasis | 269,082 | 590 | 1·13 (1·04 - 1·23) | 27,943 | 197 | 1·06 (0·92 - 1·22) | 73 | 1·02 (0·81 - 1·28) | 69 | 1·02 (0·81 - 1·3) |
| Psychological and neurodegenerative diseases | ||||||||||
| Neurotic and Mood Disorders, use of antidepressant treatments | 3,488,916 | 7,510 | 1·25 (1·22 - 1·28) | 776,020 | 7,064 | 1·37 (1·33 - 1·41) | 1,026 | 1·33 (1·24 - 1·42) | 2,376 | 1·36 (1·29 - 1·43) |
| Psychotics disorders, use of neuroleptics treatments | 650,189 | 2,100 | 1·76 (1·69 - 1·85) | 112,431 | 1,284 | 1·39 (1·31 - 1·47) | 425 | 3·01 (2·71 - 3·34) | 515 | 1·63 (1·49 - 1·79) |
| Psychiatric disorders starting in childhood | 164,897 | 133 | 2·03 (1·7 - 2·41) | 725 | 13 | 1·74 (1·01 - 3) | 22 | 3·76 (2·45 - 5·77) | 3 | 1·12 (0·36 - 3·46) |
| Down syndrom | 33,508 | 208 | 6·93 (6·04 - 7·96) | 33 | 0 | 48 | 23·67 (17·61 - 31·8) | 0 | ||
| Epilepsy | 282,167 | 878 | 1·66 (1·55 - 1·78) | 38,880 | 424 | 1·22 (1·11 - 1·34) | 151 | 1·8 (1·52 - 2·12) | 141 | 1·12 (0·95 - 1·32) |
| Multiple sclerosis | 109,704 | 276 | 1·65 (1·47 - 1·87) | 3,360 | 48 | 2·29 (1·73 - 3·05) | 41 | 2·63 (1·91 - 3·63) | 17 | 2·59 (1·61 - 4·19) |
| Paraplegia | 83,637 | 378 | 2·08 (1·87 - 2·31) | 7,779 | 85 | 1·43 (1·15 - 1·77) | 71 | 2·61 (2·04 - 3·33) | 32 | 1·54 (1·09 - 2·19) |
| Myopathy or myasthenia gravis | 41,388 | 105 | 1·33 (1·09 - 1·61) | 4,803 | 48 | 1·39 (1·04 - 1·84) | 22 | 2·13 (1·4 - 3·25) | 19 | 1·57 (1 - 2·47) |
| Parkinson disease | 129,111 | 683 | 1·65 (1·53 - 1·78) | 115,619 | 1,251 | 1·42 (1·34 - 1·51) | 178 | 1·98 (1·7 - 2·31) | 467 | 1·48 (1·35 - 1·63) |
| Dementias (including Alzheimer's disease) | 125,611 | 1,418 | 2·8 (2·65 - 2·97) | 484,709 | 6,432 | 1·86 (1·8 - 1·92) | 432 | 3·31 (2·97 - 3·69) | 2,387 | 2·02 (1·91 - 2·12) |
| Mental impairment | 123,835 | 541 | 3·66 (3·35 - 3·99) | 2,345 | 42 | 4·21 (3·11 - 5·71) | 101 | 7·04 (5·71 - 8·67) | 19 | 6·1 (3·88 - 9·57) |
| Other pathologies | ||||||||||
| Hemophilia or severe hemostasis disorders | 43,908 | 109 | 1·48 (1·23 - 1·79) | 5,878 | 58 | 1·42 (1·1 - 1·84) | 16 | 1·66 (1·01 - 2·71) | 23 | 1·65 (1·1 - 2·48) |
| HIV infection | 144,393 | 562 | 1·87 (1·72 - 2·04) | 1,811 | 13 | 0·93 (0·54 - 1·6) | 59 | 1·92 (1·48 - 2·48) | 5 | 0·93 (0·39 - 2·24) |
| Liver diseases | 358,039 | 1,696 | 1·51 (1·43 - 1·59) | 39,243 | 474 | 1·3 (1·18 - 1·42) | 317 | 1·62 (1·44 - 1·83) | 170 | 1·29 (1·11 - 1·51) |
| Chronic dialysis | 32,235 | 718 | 4·71 (4·36 - 5·08) | 13,689 | 381 | 3·24 (2·92 - 3·59) | 180 | 5·16 (4·42 - 6·03) | 162 | 3·7 (3·16 - 4·34) |
| Renal transplant | 40,779 | 513 | 4·41 (4·04 - 4·82) | 1,746 | 34 | 3·05 (2·18 - 4·27) | 123 | 6·66 (5·54 - 8) | 14 | 3·65 (2·16 - 6·18) |
| Cardiac translant | 1,669 | 22 | 1·97 (1·29 - 3) | 4 | 1·51 (0·56 - 4·07) | 0 | ||||
| Liver transplant | 5,021 | 27 | 0·77 (0·52 - 1·12) | 4 | 0·56 (0·21 - 1·51) | 0 | ||||
| Lung transplant | 1,345 | 25 | 3·28 (2·18 - 4·92) | 6 | 5·05 (2·25 - 11·35) | 0 | ||||