Table 1. Statistical measures for evaluating the performance of the multitask network for both iPSC-CM AP trace classification into drug-free and drugged categories and their translation into adult-CM APs for training and test datasets as well as the effect of removing LSTM layers and classification task on the network performance.
Translation | |||||||
---|---|---|---|---|---|---|---|
Performance metrics | MSE | R2 score | Error in APD90 prediction | ||||
Training dataset | 0.0027 | 0.992 | 3.41% | ||||
Test dataset | 0.0029 | 0.991 | 3.60% | ||||
Remove LSTM layers test dataset | 0.0031 | 0.991 | 3.78% | ||||
Remove classification task test dataset | 0.0034 | 0.990 | 4.33% | ||||
Classification | |||||||
Performance metrics | AUROC | Accuracy | Recall | Precision | |||
Training dataset | 0.93 | 92% | 0.92 | 0.93 | |||
Test dataset | 0.91 | 92% | 0.92 | 0.92 | |||
Remove LSTM layers test dataset | 0.90 | 92% | 0.90 | 0.91 | |||
iPSC-CM: induced pluripotent stem cell-derived cardiomyocyte; AP: action potential; adult-CM: adult cardiomyocyte; AP: action potential; AUROC: area under the receiver operating characteristic curve; LSTM: long-short-term-memory. |