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. 2021 Jul 1;12:708806. doi: 10.3389/fimmu.2021.708806

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Copyright © 2021 Umotoy and de Taeye

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of Antibody Conjugates. Representative antibody conjugates described in this review (1) eCD4-Ig is the conjugation of CD4 to a CCR5 mimetic peptide inhibiting viral fusion and entry, (2) ²¹³Bi-2556 is an antibody-radionuclide with ²¹³Bi fused to an antibody targeting gp41, this conjugate delivers cytocidal radiation upon binding inducing DNA break, (3) 3B3(Fv)PE-38 is an antibody-toxin constructed with the scFv subunit of b12 bNAb conjugated to PE toxin and functions by inhibiting protein synthesis upon internalization, (4) 4M5.3-3X4 is an antibody-oligonucleotide designed with a nanobody targeting CXCR4 conjugated with an anti-tat siRNA, inhibiting Tat-driven transcription.