Table 2.
Virus-directed antibody conjugates.
| Antibody Conjugate | Target | Carrier | Payload | Payload Type | Reference |
|---|---|---|---|---|---|
| 7B2-PIT | gp41 | 7B2 mAb | Porphyrin, IR700 | Photosensitizer | (32) |
| rCD4-dgA | gp120 | CD4 Receptor | Ricin A chain | Toxin | (33) |
| CD4 (178)-PE40 | gp120 | CD4 Receptor | Pseudomonas exotoxin | Toxin | (34) |
| 907-RAC | gp120 | 907mAb | Ricin A chain | Toxin | (35) |
| 0.5β-RAC | gp120 | 0.5β mAb | Ricin A chain | Toxin | (36) |
| 0.5β-PE | gp120 | 0.5β mAb | Pseudomonas exotoxin | Toxin | (36) |
| DAB389-CD4 | gp120 | CD4 Receptor | Diptheria toxin | Toxin | (37) |
| 3B3(Fv)-PE38 | gp120 | 3B3 scFv | Pseudomonas exotoxin | Toxin | (38) |
| 924-RAC | gp120 | 924mAb | Ricin A chain | Toxin | (39) |
| 924-PAC | gp120 | 924mAb | Pulchellin A chain | Toxin | (40) |
| Anti-gp160-RAC | gp160 | Anti-gp160 mAb | Ricin A chain | Toxin | (41) |
| 7B2-RAC | gp41 | 7B2 mAb | Ricin A chain | Toxin | (39) |
| 41.1-RAC | gp41 | 41.1 mAb | Ricin A chain | Toxin | (39) |
| 7B2-PAC | gp41 | 7B2 mAb | Pulchellin A chain | Toxin | (40) |
| F105-P-gag | gp120 | F105 Fab | gag-siRNA | siRNA | (42) |
| scFvCD7-9R-vif | Vif | Anti-CD7 scFv | vif-siRNA | siRNA | (43) |
| scFvCD7-9R-tat | Tat | Anti-CD7 scFv | tat-siRNA | siRNA | (43) |
| 188-Re-246-D | gp41 | 246-D mAb | 188-Re | Radionuclide | (44) |
| 213-Bi-246-D | gp41 | 246-D mAb | 213-Bi | Radionuclide | (44) |
| 213-Bi-2556 | gp41 | 2556 mAb | 213-Bi | Radionuclide | (45) |
| 225-Ac-2556 | gp41 | 2556 mAb | 225-Ac | Radionuclide | (46) |
| 177-Lu-2556 | gp41 | 2556 mAb | 177-Lu | Radionuclide | (46) |
| Dox-P4/D10 | gp120 | P4/D10 mAb | Doxorubicin | Drug | (47) |
| e10-1074 | V3-glycan | 10-1074 bNAb | CCR5mim6 | Inhibitor | (48) |
| ePGT121 | V3-glycan | PGT121 bNAb | CCR5mim6 | Inhibitor | (48) |
| ePGT122 | V3-glycan | PGT122 bNAb | CCR5mim6 | Inhibitor | (48) |
| ePGT128 | V3-glycan | PGT128 bNAb | CCR5mim6 | Inhibitor | (48) |
| e3BNC117 | CD4bs | 3BNC117 | CCR5mim6 | Inhibitor | (48) |
| ePGDM1400 | V2-apex | PGDM1400 | CCR5mim6 | Inhibitor | (48) |
| ePGT151 | gp120-gp41 interface | PGT151 bNAb | CCR5mim6 | Inhibitor | (48) |
| e10E8 | MPER | 10E8 bNAb | CCR5mim6 | Inhibitor | (48) |
| eE51 | CD4i | E51 bNAb | CCR5mim6 | Inhibitor | (48) |
| 50-69-RAC | gp41 | 50-69 mAb | Ricin A chain | Toxin | (49) |
| gp120-brefeldin A | gp120 | Anti-gp120 Polyclonal Ab | Brefeldin A | Drug | (50) |
| 2F5-Cholesterol | gp120/membrane | 2F5 bNAb | Cholesterol | Lipid | (51) |
| eCD4-Ig | gp120 | Anti-CCR5 mAb | CCR5mim1 | Small drug | (52) |