Table 3.
Host-directed antibody conjugates.
| Antibody Conjugate | Target | Carrier | Payload | Payload Type | Reference |
|---|---|---|---|---|---|
| Anti-CD25-RAC | CD25 | Anti-CD25 mAb | Ricin A chain | Toxin | (64) |
| Anti-CD4-PAP | CD4 | Anti-CD4 mAb | Pokeweed antiviral protein | Toxin | (65) |
| Anti-CD45RO IT | CD45RO | Anti-CD45RO mAb | Ricin A chain | Toxin | (66) |
| Anti-CD5-PAP | CD5 | Anti-CD5 mAb | Pokeweed antiviral protein | Toxin | (65) |
| Anti-CD7-PAP | CD7 | Anti-CD7 mAb | Pokeweed antiviral protein | Toxin | (65) |
| DAB486-IL2 | IL2R | IL2 | Diphtheria toxin | Toxin | (67) |
| DAB389-IL-2 | IL2R | IL2 | Diphtheria toxin | Toxin | (68) |
| AL-57-PF-CCR5 | LFA-1 | AL-57 scFv | CCR5-siRNA | siRNA | (69) |
| CD7-9R-CD4-siRNA | CD4 | Anti-CD7 scFv | CD4-siRNA | siRNA | (43) |
| CD7-9R-CCR5-siRNA | CCR5 | Anti-CD7 | CCR5-siRNA | siRNA | (43) |
| 4M5.3-3X4 | CXCR4 | Anti-CXCR4 scFv | tat-siRNA | siRNA | (70) |
| CCR5mAb-FI | CCR5 | Anti-CCR5 mAb | T-2635 | Small drug | (71) |
| 38C2-Apalviroc | CCR5 | 38C2 cpAb | Aplaviroc | Small drug | (72) |
| cP4/D10-T20 | gp120 | P4/D10 mAb | Enfuvirtide | Small drug | (73) |
| 38C2-BMS-488043 | CCR5 | 38C2 cpAb | BMS-488043 | Small drug | (74) |
| 38C2-Maraviroc | CCR5 | 38C2 cpAb | Maraviroc | Small drug | (75) |