Table 7.
Main pharmacokinetic parameters of TP and PF in rats.
| Parameters | Triptolide | Paeoniflorin | ||
|---|---|---|---|---|
| TP | TP-PF | PF | TP-PF | |
| C max (μg/L) | 63.42 ± 17.40 | 36.89 ± 12.73 | 22383.66 ± 7768.60 | 53314.70 ± 19958.50 |
| T max (h) | 0.88 ± 0.23 | 2.25 ± 1.23 | 0.75 ± 0.29 | 2.08 ± 2.11 |
| t1/2z (h) | 26.18 ± 17.22 | 59.15 ± 63.89 | 37.27 ± 12.70 | 16.37 ± 8.05 |
| AUC (0-t) (μg/L∗h) | 247.95 ± 54.35 | 289.57 ± 37.30 | 113701.69 ± 7470.15 | 214379.35 ± 24618.58∗∗ |
| AUC (0-∞) (μg/L∗h) | 569.22 ± 264.16 | 987.70 ± 728.02∗∗ | 287530.42 ± 98387.10 | 337060.99 ± 120757.76 |
| MRT (0-t) (h) | 7.56 ± 1.22 | 9.42 ± 0.84 | 8.58 ± 0.71 | 7.58 ± 1.36 |
| MRT (0-∞) (h) | 30.85 ± 22.54 | 82.67 ± 90.21 | 50.01 ± 19.60 | 22.86 ± 12.40 |
| CLz/F (L/h/kg) | 2.01 ± 0.74 | 1.35 ± 0.63 | 3.78 ± 1.22 | 3.25 ± 1.07 |
| Vz/f (L/kg) | 82.04 ± 51.74 | 73.98 ± 23.85 | 68.22 ± 18.27 | 187.44 ± 5.28 |
Compared with the monodrug group, ∗P < 0.05 and ∗∗P < 0.01.