Table 2.
The survival rate percent of intact neurons in the cerebral cortex, different hippocampal regions and amyloid plaques recorded in the brain of the mice.
| Groups | Survival rate percent of intact neurons | Amyloid plaques | |||
|---|---|---|---|---|---|
| Cerebral cortex | CA3 | CA4 | DG | Cerebral cortex + hippocampus | |
| Sham control | 95.3 ± 1.5 | 92.3 ± 1.5 | 89.0 ± 1.0 | 92.3 ± 1.5 | — |
| STZ model | 44.7 ±2.1∗∗∗∗ | 27.3 ± 1.5∗∗∗∗ | 31.0 ± 1.0∗∗∗∗ | 36.0 ± 1.0∗∗∗∗ | 12 (10-18)∗∗∗∗ |
| STZ + simvastatin | 89.0 ± 1.0∗∗#### | 82.3 ± 1.5∗∗#### | 71.0 ± 1.0∗∗∗∗#### | 81.0 ± 1.0∗∗∗∗#### | 2.5 (0-5)∗## |
| STZ+ PFT (100 mg/kg) | 73.3 ± 1.5∗∗∗∗#### | 77.7 ±2.1∗∗∗∗#### | 60.7 ± 1.5∗∗∗∗#### | 71.7 ± 1.5∗∗∗∗#### | 3 (2-6)∗∗# |
| STZ+ PFT (300 mg/kg) | 83.0 ±2.0∗∗∗∗#### | 81.0 ± 1.0∗∗∗#### | 66.3 ± 1.5∗∗∗∗#### | 71.7 ± 1.5∗∗∗∗#### | 3 (1-5)∗∗# |
| STZ+ PFT (600 mg/kg) | 85.7 ± 1.5∗∗∗#### | 85.7 ± 4.7∗#### | 77.3 ± 1.5∗∗∗∗#### | 80.7 ± 1.5∗∗∗∗#### | 2.5 (0-4)### |
Data of survival rate percent of intact neurons represents the mean ± SD of 3 mice per group and data of amyloid plaques represents the median and range of 3 mice per group; ∗ significantly different from sham control group at p <0.05, ∗∗ significantly different from sham control group at p <0.01, ∗∗∗ significantly different from sham control group at p <0.001, ∗∗∗∗∗ significantly different from sham control group at p <0.0001, #significantly different from STZ group at p <0.05, ## significantly different from STZ group at p <0.01, ### significantly different from STZ group at p <0.001, #### significantly different from STZ group at p <0.0001 using one-way ANOVA followed by Tukey's multiple comparisons test for statistical analysis of survival rate, and using Kruskal–Wallis one-way ANOVA followed by Dunn's multiple comparisons test for statistical analysis of amyloid plaque number.