Table 3.
Association of genotype and allele distribution of SNPs in CD14, NF-κΒ, TLR2, and TLR4 and periodontal disease severity.
| All patients | No or mild periodontitis | Severe periodontitis | p value | |
|---|---|---|---|---|
| CD14: rs2569190 | ||||
| n = 928 | n = 487 | n = 441 | ||
| CC (%) | 30.4 | 29.8 | 31.1 | 0.182 |
| CT (%) | 46.6 | 44.8 | 48.5 | |
| TT (%) | 23.0 | 25.4 | 20.4 | |
| n = 1856 | n = 974 | n = 882 | ||
| C (%) | 53.7 | 52.2 | 55.3 | 0.186 |
| T (%) | 46.3 | 47.8 | 44.7 | |
|
| ||||
| NF-κΒ: rs28362491 | ||||
| n = 927 | n = 487 | n = 440 | ||
| II (%) | 33.0 | 31.8 | 34.3 | 0.581 |
| ID (%) | 51.4 | 51.5 | 51.1 | |
| DD (%) | 15.6 | 16.6 | 14.6 | |
| n = 1854 | n = 974 | n = 880 | ||
| I (%) | 58.7 | 57.6 | 59.9 | 0.341 |
| D (%) | 41.3 | 42.4 | 40.1 | |
|
| ||||
| TLR2: rs5743708 | ||||
| n = 939 | n = 493 | n = 446 | ||
| AA (%) | 94.5 | 93.7 | 95.3 | 0.389∗ |
| AG (%) | 5.4 | 6.1 | 4.7 | |
| GG (%) | 0.1 | 0.2 | 0 | |
| n = 1878 | n = 986 | n = 892 | ||
| A (%) | 97.2 | 96.8 | 97.6 | 0.305 |
| G (%) | 2.8 | 3.2 | 2.4 | |
|
| ||||
| TLR4: rs4986790 | ||||
| n = 942 | n = 494 | n = 448 | ||
| AA (%) | 91.4 | 92.7 | 90.0 | 0.237∗ |
| AG (%) | 8.4 | 7.1 | 9.8 | |
| GG (%) | 0.2 | 0.2 | 0.2 | |
| n = 1884 | n = 988 | n = 896 | ||
| A (%) | 95.6 | 96.3 | 94.9 | 0.175 |
| G (%) | 4.4 | 3.7 | 5.1 | |
∗Fisher's exact test.