Table 4.
Association of genotype and allele distribution of SNPs in CD14. NF-κΒ. TLR2 and TLR4 and occurrence of combined endpoint (stroke/TIA. myocardial infarction. Cardiovascular death. Death from stroke).
| All patients | No or mild periodontitis | Severe periodontitis | p value | |
|---|---|---|---|---|
| CD14: rs2569190 | ||||
| n = 881 | n = 740 | n = 141 | ||
| CC (%) | 30.6 | 31.9 | 24.1 | 0.074 |
| CT (%) | 46.2 | 44.6 | 54.6 | |
| TT (%) | 23.2 | 23.5 | 21.3 | |
| n = 1762 | n = 1480 | n = 282 | ||
| C (%) | 53.7 | 54.2 | 51.4 | 0.429 |
| T (%) | 46.3 | 45.8 | 48.6 | |
|
| ||||
| NF-κΒ: rs28362491 | ||||
| n = 880 | n = 738 | n = 142 | ||
| II (%) | 32.7 | 33.5 | 28.9 | 0.537 |
| ID (%) | 51.4 | 50.9 | 53.5 | |
| DD (%) | 15.9 | 15.6 | 17.6 | |
| n = 1760 | n = 1476 | n = 284 | ||
| I (%) | 58.4 | 58.9 | 55.6 | 0.332 |
| D (%) | 41.6 | 41.1 | 44.4 | |
|
| ||||
| TLR2: rs5743708 | ||||
| n = 892 | n = 749 | n = 143 | ||
| AA (%) | 94.5 | 94.4 | 95.1 | 1.000∗ |
| AG (%) | 5.4 | 5.5 | 4.9 | |
| GG (%) | 0.1 | 0.1 | 0 | |
| n = 1784 | n = 1498 | n = 286 | ||
| A (%) | 97.2 | 97.1 | 97.6 | 0.840 |
| G (%) | 2.8 | 2.9 | 2.4 | |
|
| ||||
| TLR4: rs4986790 | ||||
| n = 895 | n = 751 | n = 144 | ||
| AA (%) | 91.2 | 91.5 | 89.6 | 0.590∗ |
| AG (%) | 8.6 | 8.3 | 10.4 | |
| GG (%) | 0.2 | 0.2 | 0.0 | |
| n = 1790 | n = 1502 | n = 288 | ||
| A (%) | 95.5 | 95.6 | 94.8 | 0.650 |
| G (%) | 4.5 | 4.4 | 5.2 | |
∗Fisher's exact test.