Table 1.

Domain assessments (X is all domains, O is viral domain only, & is clinical domain only).

Day of study	1	2	3	4	5	6	7	8	9	10	14	21	28	35
Assessments in the clinic	X				X					O			X
Physical exam	X				X					O			X
Vitals	X				X					O			X
Clinical status	X				X					O			X
SpO2	X				X					O			X
Self-collected nasal swab and self-assessmenta	X	X	X	X	X	X	X	X	X	O	X	X	X
Oropharyngeal swab	X				X					O			X
Blood collected by phlebotomy for clinical labs (CBC, Chem 7, LFTs)	X				X					O			X
Blood collected by phlebotomy for biobanking/immunology studies	X												X
Blood collected by phlebotomy for PK (if applicable)	X				X					O
Telehealth visit										&	X	X		X

^aNote: Symptom self-assessment through COSS occurs every day from day 1 through 28.