Table 2.

Operating characteristics for Scenario A when 4 drugs are assessed and none are effective: Prob 1 (probability that at least 1 drug incorrectly identified as effective) and Prob 2 (probability that at least 2 drugs incorrectly identified as effective) by proportion of shared controls under COPPS (estimated from simulation) relative to 4 independently run trials with no shared controls (theoretically derived probabilities).

COPPS			Four independent trials No shared controls
Proportion of shared controls	Prob 1	Prob 2	Prob 1	Prob 2
3.3% (2/60)	0.184	0.013	0.188	0.013
50% (30/60)	0.178	0.017
96.6% (58/60)	0.159	0.033