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. 2021 Jul 16;39(35):4988–5001. doi: 10.1016/j.vaccine.2021.07.034

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 7 — Weight change of hamsters after exposure to SARS-CoV-2. Hamsters from experiment described in Fig. 6 were monitored daily for weight change. Results are represented for each animal in each groups as kinetic of weight change from SARS-CoV-2 exposure to day 9 after infection. (a) represents the weight change observed in the 2-dose regimen (II), (b) represent the weight change observed in the single dose regimen (I). One animal from Saline group II and one animal from VBI-2902(II) were sacrificed at day 6 and day 7 respectively, because they presented intense distress. Animal from Saline(II) presented typical clinical signs of SARS-CoV-2 infection. Severe clinical presentation of animal in VBI-2902a(II) could not be related to SARS-CoV-2 infection and have not been determined. Significant days of weight loss relative to Saline group (p < 0.005) are indicated on the left panel. Statistical analysis was performed with unpaired non parametric multiple t test using Holm-Šidák method.