Table 3.

Subgroup Analysis for Nonfatal Events^a,bc

Outcome by risk intervals	COVID-19 hospitalization			Age, y			Sex
	Yes	No	Pinteraction	≤75	>75	Pinteraction	Female	Male	Pinteraction
	IRR (95% CI)	IRR (95% CI)		IRR (95% CI)	IRR (95% CI)		IRR (95% CI)	IRR (95% CI)
Composite
5-1 days before	12.45 (7.37-21.03)	2.48 (1.33-4.63)	.0001	3.80 (2.44-5.93)	2.60 (1.81-3.72)	.19	2.22 (1.41-3.47)	4.31 (3.02-6.15)	.03
0-7 days after	36.97 (28.69-47.64)	4.07 (2.83-5.85)	<.0001	22.78 (17.58-29.53)	5.94 (4.35-8.12)	<.0001	6.36 (4.47-9.04)	19.44 (15.38-24.58)	<.0001
8-28 days after	6.16 (4.18-9.09)	1.82 (1.26-2.63)	<.0001	5.79 (4.16-8.07)	1.24 (0.78-1.97)	<.0001	2.64 (1.83-3.82)	3.19 (2.18-4.66)	.50
28-56 days after	4.85 (3.27-7.20)	1.50 (1.04-2.17)	<.0001	4.27 (3.03-6.03)	1.12 (0.72-1.74)	<.0001	2.28 (1.59-3.27)	2.46 (1.66-3.65)	.79
Myocardial infarction
5-1 days before	3.58 (0.86-14.88)	6.17 (2.73-13.95)	.52	4.14 (2.00-8.54)	3.36 (1.80-6.26)	.67	4.29 (2.15-8.58)	3.47 (1.82-6.60)	.66
0-7 days after	8.09 (3.87-16.90)	3.38 (1.50-7.65)	.12	6.19 (2.85-13.42)	3.65 (1.69-7.88)	.34	3.35 (1.22-9.18)	6.45 (3.46-12.00)	.28
8-28 days after	1.00 (0.24-4.17)	1.85 (0.86-3.96)	.46	2.49 (1.08-5.77)	0.77 (0.24-2.45)	.11	1.58 (0.57-4.39)	1.43 (0.58-3.50)	.89
28-56 days after	1.28 (0.39-4.22)	1.15 (0.47-2.81)	.89	1.01 (0.32-3.23)	0.97 (0.35-2.64)	.96	1.41 (0.51-3.92)	0.94 (0.34-2.57)	.60
Ischemic stroke
5-1 days before	3.23 (0.79-13.30)	1.62 (0.52-5.06)	.45	1.70 (0.54-5.39)	1.84 (1.00-3.37)	1.00	1.21 (0.50-2.96)	2.58 (1.32-5.08)	.18
0-7 days after	14.03 (8.11-24.27)	4.22 (2.50-7.12)	.0019	17.81 (10.67-29.72)	3.63 (2.07-6.38)	<.0001	2.05 (0.84-5.00)	13.27 (8.79-20.04)	.0002
8-28 days after	1.26 (0.39-4.07)	0.51 (0.19-1.37)	.25	0.45 (0.06-3.27)	0.81 (0.36-1.84)	1.00	0.75 (0.28-2.03)	0.72 (0.23-2.26)	.96
28-56 days after	2.37 (1.06-5.29)	0.60 (0.27-1.36)	.02	1.46 (0.53-4.02)	0.93 (0.47-1.83)	.47	1.20 (0.59-2.45)	0.96 (0.39-2.37)	.75
Pulmonary embolism
5-1 days before	50.25 (24.26-104.07)	2.09 (0.52-8.44)	.0001	5.36 (2.60-11.08)	3.40 (1.64-7.03)	.39	1.98 (0.73-5.37)	8.10 (4.42-14.86)	.02
0-7 days after	135.97 (88.89-207.98)	3.92 (1.83-8.40)	<.0001	46.84 (32.21-68.12)	10.36 (5.99-17.91)	<.0001	15.22 (9.30-24.90)	43.82 (29.78-64.48)	.001
8-28 days after	23.97 (14.03-40.97)	3.54 (2.03-6.16)	<.0001	12.64 (8.20-19.49)	2.04 (0.93-4.48)	.0001	5.77 (3.42-9.71)	9.35 (5.63-15.54)	.20
28-56 days after	16.26 (9.35-28.27)	2.99 (1.74-5.15)	<.0001	8.13 (5.16-12.81)	1.88 (0.90-3.94)	.0009	4.98 (3.02-8.21)	6.21 (3.58-10.77)	.57
Deep vein thrombosis
5-1 days before	24.07 (5.54-104.49)	1.82 (0.25-13.20)	.04	2.20 (0.54-9.04)	3.83 (1.51-9.69)	1.00	3.18 (1.16-8.73)	3.90 (1.20-12.65)	.80
0-7 days after	92.44 (46.02-185.68)	3.77 (1.36-10.46)	<.0001	24.21 (13.13-44.64)	10.59 (5.11-21.97)	.09	8.04 (3.49-18.57)	33.91 (18.80-61.18)	.006
8-28 days after	9.54 (3.15-28.93)	2.75 (1.18-6.40)	.08	5.30 (2.38-11.80)	1.74 (0.53-5.68)	.13	4.89 (2.33-10.26)	2.03 (0.49-8.45)	.33
28-56 days after	1.46 (0.19-11.55)	2.35 (1.01-5.46)	.67	2.85 (1.11-7.28)	0.91 (0.22-3.82)	.19	1.41 (0.44-4.50)	3.49 (1.23-9.90)	.26

^aCOVID-19, coronavirus disease 2019; IRR: incidence rate ratio.

^bPatients' age quintile was adjusted.

^cBold type indicates P_interaction < .05