Table 4.
Observed versus expected venous and arterial thromboembolic and hemorrhagic events after COVID-19 vaccination
| Age group | Number study individuals vaccinated | Venous thromboembolic events (including CVST) | Arterial thromboembolic events | Hemorrhagic events | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Observed eventsa | Expected number of eventsb | Observed–expected (95% CI) | Observed eventsa | Expected number of eventsb | Observed–expected (95% CI) | Observed eventsa | Expected number of eventsb | Observed–expected (95% CI) | ||
| ChAdOx1 | ||||||||||
| 16–39 | 181,635 | 30 | 11.1 | 18.90 (8.42–30.25) | 15 | 4.3 | 10.67 (3.33–18.81) | 9 | 5.0 | 4.04 (−1.57–10.47) |
| 40–59 | 740,800 | 178 | 106.9 | 71.11 (41.66–100.51) | 516 | 283.8 | 232.23 (182.63–282.63) | 58 | 41.9 | 16.13 (−0.85–34.07) |
| 60–79 | 606,854 | 439 | 423.4 | 15.60 (−44.53–74.57) | 1,600 | 1,521.0 | 78.96 (−32.80–188.70) | 131 | 149.9 | −18.85 (−52.50–14.35) |
| 80+ | 178,673 | 246 | 275.3 | −29.28 (−83.56–25.40) | 1,157 | 1,519.0 | −362.03 (−488.57–239.94) | 103 | 151.9 | −48.95 (−87.64–10.46) |
| BNT162b2 | ||||||||||
| 16–39 | 144,393 | 24 | 22.9 | 1.09 (−9.34–12.21) | 5 | 8.9 | −3.90 (−8.95–1.79) | 10 | 10.2 | −0.24 (−6.86–7.11) |
| 40–59 | 230,802 | 80 | 97.3 | −17.29 (−38.85–4.78) | 217 | 258.0 | −41.00 (−76.37–4.39) | 37 | 38.1 | −1.11 (−15.32–13.30) |
| 60–79 | 409,429 | 259 | 357.2 | −98.22 (−144.82–51.85) | 1,156 | 1,283.4 | −127.38 (−222.72–35.17) | 88 | 126.4 | −38.41 (−65.85–11.24) |
| 80+ | 36,428 | 58 | 66.0 | −8.00 (−26.38–11.01) | 225 | 364.0 | −138.96 (−177.19–99.42) | 29 | 36.4 | −7.43 (−20.35–6.31) |
aThe observed events were incident cases after vaccination counted for the observed duration of the post-vaccination period. bThe expected events are the number of events per day in the pre-vaccination period divided by the population and multiplied by the days at risk in the post-vaccination period for all vaccinated and then summed. cThe difference between expected (the number of events per day in the pre-vaccination period divided by the population and multiplied by the days at risk in the post-vaccination period for all vaccinated and then summed) and observed events during the post-vaccination period, with CIs obtained from a parametric bootstrap, was based on the Poisson distribution using 10,000 samples. There was limited opportunity for matching in this analysis, and the findings, therefore, need to be interpreted with caution.