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. 2020 Nov 5;52(1):42–47. doi: 10.1007/s11239-020-02331-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Enterochromaffine cells (EC-cells) in the gut express Tph1 and synthesize the majority of peripheral serotonin (5-HT). EC-cells release 5-HT into the blood plasma, where it is taken up by platelets (blue rectangles) via SERT. Platelets, as the main circulating reservoir, store 5-HT in their dense granules. Upon activation, platelet dense granules release 5-HT. 5-HT can amplify the release of dense granules via activation of the 5-HT2A receptor