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. 2021 Jul 15;16(1):113. doi: 10.1007/s11657-021-00956-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Results of deterministic sensitivity analyses. The figure presents the incremental cost-effectiveness ratios (ICERs) of zoledronic acid compared with sequential denosumab/alendronate at different starting ages, when the parameter estimates varied across its ranges of plausible values. The public healthcare and long-term care payer’s perspective is taken. The green bars represent the ranges of possible values in deterministic sensitivity analyses (cut off on right-hand side for ease of display). The vertical hashed line represents the predetermined thresholds of willingness-to-pay of $47,500 (¥5 million) or $95,000 (¥10 million) per quality-adjusted life-year. The ICERs of deterministic sensitivity analyses that became less than the predetermined thresholds of willingness-to-pay were presented