Fig. 1.

Clinical picture of PBC and PSC. a Cholangiography of the PSC by ERCP. There are multiple stenoses in the bile duct (yellow arrowhead, diverticulum-like outpunching; orange arrowhead, band-like stricture). b Histopathology of PSC obtained by liver biopsy. There is “onion-skin fibrosis” around intrahepatic small bile ducts. c Histopathology of PBC obtained by liver biopsy. The findings of chronic non-suppurative destructive cholangitis. ERCP endoscopic retrograde cholangiopancreatography, PBC primary biliary cholangitis, PSC primary sclerosing cholangitis