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. 2021 Jul 15;6:60. doi: 10.1038/s41525-021-00227-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The number of candidate variants for 149 exome trios are separated by inheritance mode and colored by variant class. Variants deemed impactful by slivar using annotations from VEP, snpEff, and bcftools. Counts for autosomal dominant variants are shown in a separate plot due to the much larger numbers. Each point represents the number of candidate variants for a single family (y-axis) passing the inheritance mode (x-axis), genotype-quality, population allele-frequency, and allele-balance filters. Gray bars indicate the mean number for each class and inheritance mode. Points are jittered slightly to allow viewing more samples simultaneously.