Table 1.

Recommended filtering parameters.

Description	Filter
High genotype quality for all samples in a family	GQ ≥ 20
Allele balance between 0.2 and 0.8 for heterozygous samples	0.2 ≤ AB ≤ 0.8
Allele balance <0.02 homozygous samples	AB < 0.02
Depth of at least 10 for all samples in a family in whole-genome data	DP ≥ 10 (whole-genome only)
Low allele-frequency (or absent) in population allele-frequency databases	population_AF < 0.01 (recessive inheritance modes)
	population_AF < 0.001 (dominant inheritance modes)