Table 5.
The association between alcohol drinking and pancreatic cancer risk stratified by the genotypes of ADH1B or ALDH2.
|
Cases n (%) |
Controls n (%) |
OR (95% CI)a |
Cases n (%) |
Controls n (%) |
OR (95% CI)a | |
|---|---|---|---|---|---|---|
| ADH1B rs1229984 | Fast ADH1B (*2/*2) | Slow ADH1B (*1/*1 + *1/*2) | ||||
| Drinking status | ||||||
| Never | 81 (38.9) | 175 (34.9) | Reference | 65 (33.7) | 138 (33.1) | Reference |
| Occasional | 79 (38.0) | 241 (48.0) | 0.74 (0.48–1.14) | 84 (43.5) | 227 (54.4) | 0.92 (0.57–1.47) |
| Former regular | 19 (9.1) | 38 (7.6) | 0.70 (0.33–1.49) | 13 (6.7) | 17 (4.1) | 0.78 (0.29–2.12) |
| Current regular | 29 (13.9) | 48 (9.6) | 0.94 (0.47–1.88) | 31 (16.1) | 35 (8.4) | 1.35 (0.63–2.89) |
| P-interaction = 0.39 | ||||||
| Frequency | ||||||
| Never | 81 (38.9) | 175 (34.9) | Reference | 65 (33.7) | 138 (33.1) | Reference |
| Occasional | 79 (38.0) | 241 (48.0) | 0.73 (0.47–1.13) | 84 (43.5) | 227 (54.4) | 0.92 (0.57–1.47) |
| Monthly | 3 (1.4) | 5 (1.0) | 1.55 (0.30–7.92) | 3 (1.6) | 7 (1.7) | 0.63 (0.12–3.18) |
| Weekly | 10 (4.8) | 31 (6.2) | 0.40 (0.16–1.02) | 11 (5.7) | 18 (4.3) | 1.12 (0.38–3.33) |
| Daily | 29 (13.9) | 45 (9.0) | 0.87 (0.43–1.77) | 23 (11.9) | 24 (5.8) | 1.10 (0.47–2.61) |
| Unknown | 6 (2.9) | 5 (1.0) | – | 7 (3.6) | 3 (0.7) | – |
| P-interaction = 0.42 | ||||||
| Level | ||||||
| Never | 81 (38.9) | 175 (34.9) | Reference | 65 (33.7) | 138 (33.1) | Reference |
| Occasional | 79 (38.0) | 241 (48.0) | 0.73 (0.48–1.14) | 84 (43.5) | 227 (54.4) | 0.92 (0.57–1.47) |
| Light | 25 (12.0) | 51 (10.2) | 0.70 (0.33–1.44) | 17 (8.8) | 38 (9.1) | 0.56 (0.24–1.34) |
| Moderate | 2 (1.0) | 8 (1.6) | 0.20 (0.03–1.23) | 4 (2.1) | 5 (1.2) | 1.74 (0.38–8.00) |
| Heavy | 10 (4.8) | 18 (3.6) | 0.80 (0.31–2.10) | 13 (6.7) | 6 (1.4) | 2.34 (0.65–8.49) |
| Unknown | 11 (5.3) | 9 (1.8) | – | 10 (5.2) | 3 (0.7) | – |
| P-interaction = 0.15 | ||||||
| ALDH2 rs671 | Normal ALDH2 (*1/*1) | Slow/non-functional ALDH2 (*1/*2 + *2/*2) | ||||
| Drinking status | ||||||
| Never | 54 (28.0) | 127 (28.2) | Reference | 96 (44.4) | 191 (39.0) | Reference |
| Occasional | 84 (43.5) | 238 (52.9) | 0.97 (0.59–1.57) | 81 (37.5) | 239 (48.8) | 0.66 (0.44–1.01) |
| Former regular | 16 (8.3) | 30 (6.7) | 0.80 (0.33–1.92) | 18 (8.3) | 29 (5.9) | 0.66 (0.30–1.48) |
| Current regular | 39 (20.2) | 55 (12.2) | 1.11 (0.53–2.32) | 21 (9.7) | 31 (6.3) | 1.11 (0.52–2.33) |
| P-interaction = 0.61 | ||||||
| Frequency | ||||||
| Never | 54 (28.0) | 127 (28.2) | Reference | 96 (44.4) | 191 (39.0) | Reference |
| Occasional | 84 (43.5) | 238 (52.9) | 0.96 (0.59–1.56) | 81 (37.5) | 239 (48.8) | 0.66 (0.44–1.01) |
| Monthly | 3 (1.5) | 8 (1.8) | 0.96 (0.20–4.69) | 3 (1.4) | 5 (1.0) | 0.98 (0.19–5.11) |
| Weekly | 12 (6.2) | 28 (6.2) | 0.54 (0.20–1.46) | 9 (4.2) | 23 (4.7) | 0.63 (0.24–1.66) |
| Daily | 31 (16.1) | 46 (10.2) | 0.91 (0.41–2.03) | 23 (10.6) | 27 (5.5) | 1.04 (0.48–2.23) |
| Unknown | 9 (4.7) | 3 (0.7) | – | 4 (1.8) | 5 (1.0) | – |
| P-interaction = 0.63 | ||||||
| Level | ||||||
| Never | 54 (28.0) | 127 (28.2) | Reference | 96 (44.4) | 191 (39.0) | Reference |
| Occasional | 84 (43.5) | 238 (52.9) | 0.95 (0.58–1.55) | 81 (37.5) | 239 (48.8) | 0.66 (0.44–1.01) |
| Light | 25 (13.0) | 56 (12.4) | 0.58 (0.26–1.30) | 18 (8.3) | 35 (7.1) | 0.78 (0.36–1.69) |
| Moderate | 4 (2.1) | 8 (1.8) | 0.63 (0.15–2.66) | 2 (0.9) | 7 (1.4) | 0.34 (0.05–2.44) |
| Heavy | 14 (7.3) | 16 (3.6) | 1.33 (0.49–3.61) | 10 (4.6) | 10 (2.0) | 1.13 (0.39–3.29) |
| Unknown | 12 (6.2) | 5 (1.1) | – | 9 (4.2) | 8 (1.6) | – |
| P-interaction = 0.61 | ||||||
CI confidence interval, N number, OR odds ratio.
aOR and 95% CI were calculated using unconditional logistic regression, adjusted for sex, age, education, cigarette smoking (pack-years), oral hygiene score, vegetable consumption, allergy, diabetes/glucose intolerance and BMI at two years before the pancreatic cancer diagnosis for the cases or before the interview date for the controls.