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. 2021 Jul 15;12:4339. doi: 10.1038/s41467-021-24639-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Prediction of PIP-binding for 175 human PH domains using the RFC-matrix. Each vertical black line represents one PH domain. The red line indicates the cutoff value (2.59) for PIP-binding. b A binary representation of results of SiMPull assays for 20 predicted PIP binders against various vesicles. *PSD3 was assayed against all 7 PIPs and did not bind any. Blue: binding; peach: no binding; white: not tested. c A binary representation of results of SiMPull assays for 11 predicted PIP non-binders against various vesicles. Blue: binding; peach: no binding; white: not tested. d A confusion matrix constructed with results in (b, c), from which various parameters for accuracy metrics are shown. Source data for a are provided as a Source Data file.