Table 3:
Plasma biomarker levels and conventional laboratory measures differentiating active lupus nephritis*
Active renal SLE (n=28) | Active non-renal SLE (n=29) | Inactive SLE (n=26) | Healthy controls (n=25) | P-values | |
---|---|---|---|---|---|
Axl (pg/ml) | 3765 ± 235.3 | 2825 ± 200.7 | 2513 ± 130.0 | 2091 ± 152.6 | <0.0001 § 0.002 † 0.04 ¶ |
Ferritin (ng/ml) | 110.8 ± 25.50 | 31.2 ± 3.39 | 18.3 ± 3.96 | 15.1 ± 2.70 | <0.0001 § <0.0001 † >0.999 ¶ |
IGFBP4 (ng/ml) | 180146 ± 355 | 140049 ± 320 | 108548 ± 247 | 157269 ± 411 | 0.51 § 0.21 † >0.99 ¶ |
sTNFR2 (pg/ml) |
6966 ± 571 | 7195 ± 1002 | 5800 ± 568 | 6040 ± 1163 | 0.03 § 0.18 † >0.999 ¶ |
dsDNA Ab (titer) |
80 (0–1280) | 40 (0–160) | 0 (0–17.5) | ________ | 0.02 § 0.003 † 0.16 ¶ |
C3 (mg/dL) |
61.7 ± 7.5 | 87.2 ± 5.4 | 113.5 ± 4.5 | ________ | <0.0001 § <0.0001 † 0.09 ¶ |
Values were expressed as mean± standard deviation, except for dsDNA antibody titers (median, interquartile range)
P-value for comparison between all groups
P-value for active SLE vs. inactive SLE patients
P-value for active renal vs. active non-renal SLE patients