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. 2021 Jul 15;11:14511. doi: 10.1038/s41598-021-93861-x

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© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the protein expression levels of the total and nucleus Nrf2 and cytoplasmic HO-1 in three groups of CLP-induced septic rats. (A) The expression of total and nuclear Nrf2 in hippocampus. (B) The expression of cytoplasmic HO-1 in hippocampus. Compared with the sham group, the nuclear and total Nrf2 and HO-1were significantly (P = 0.004) increased in both the CLP + saline group and the CLP + vitamin C group 24 h after CLP modeling surgery. Compared with the CLP + saline group, the expression levels of the nuclear and total Nrf2, and HO-1 were significantly (P = 0.001) increased in the CLP + Vitamin C group. Values are expressed as mean ± standard deviation (n = 5). *P < 0.05 and **P < 0.01 compared with the sham group; ^##P < 0.01 compared with CLP + saline group. CLP cecal ligation and puncture, Nrf2 nuclear factor erythroid 2-related factor 2, HO-1 heme oxygenase-1.