Table 2.
Hazard Ratios for Risk of Death from Adjusted Time-Varying Cox Regression Models
| 28-day Mortality Hazard Ratio (95% CI) | 90-day Mortality Hazard Ratio (95% CI) | |
|---|---|---|
| Treatment haloperidol average daily dose (mg) | 0.93 (0.91 to 0.95) | 0.97 (0.96 to 0.98) |
| Interaction of time and haloperidol dose | 1.003 (1.002 to 1.004) | 1.0005 (1.0003 to 1.0007) |
| Total number of days with delirium or coma | 1.13 (1.09 to 1.17) | 1.07 (1.04 to 1.10) |
| Age | 1.04 (1.03 to 1.06) | 1.04 (1.03 to 1.05) |
| APACHE-II scorea | 1.07 (1.05 to 1.09) | 1.06 (1.05 to 1.08) |
| Sepsis | 1.84 (1.42 to 2.39) | 1.77 (1.40 to 2.23) |
| Mechanical ventilation | 2.51 (1.68 to 3.75) | 1.95 (1.38 to 2.75) |
| ICU length of stay | 0.93 (0.90 to 0.95) | 0.97 (0.99 to 0.99) |
Abbreviations: APACHE-II: Acute Physiology and Chronic Health Evaluation-II; ICU: intensive care unit
a
APACHE-II score ranges from 0 to 71; the higher the score, the more severely ill the patient and the higher the hospital mortality risk.