Table 1.
Demographic and Pathological Features of Patients Undergoing Resection or Receiving HAIC or SYS.
| Variable | Resection (N=237) |
HAIC (N=196) |
SYS (N=140) |
P Value |
|---|---|---|---|---|
| Age, years (median, range) | 67.6 (19.0–88.6) | 62.0 (30.1–85.7) | 66.1 (32.2–92.3) | <0.001* |
| Female Gender, N (%) | 105 (44.3) | 80 (40.8) | 67 (47.9) | 0.434 |
| Race, N (%) | 0.122 | |||
| White | 202 (87.1) | 172 (90.5) | 111 (82.8) | |
| Non-white | 30 (12.9) | 18 (9.5) | 23 (17.2) | |
| Missing | 5 | 6 | 6 | |
| Multifocal liver disease, N (%) | 53 (22.4) | 145 (74.0) | 105 (75.0) | <0.001* |
| Tumor size, cm, (median, range) | 5.6 (1.3–24.0) | 8.6 (1.0–19.5) | 8.0 (2.7–19.6) | <0.001* |
| Grade | 0.003* | |||
| Well differentiated | 2 (0.9) | 5 (2.9) | 3 (2.6) | |
| Moderately differentiated | 167 (72.9) | 97 (55.4) | 70 (60.3) | |
| Poorly differentiated | 60 (26.2) | 73 (41.7) | 43 (37.1) | |
| Missing | 8 | 21 | 24 | |
| Lymphadenectomy, N (%) | 136 (57.4) | 137 (69.9) | N/A | 0.009* |
| Treatment Era, N (%) | <0.001* | |||
| 1999–2009a | 102 (43.0) | 74 (37.8) | 22 (15.7) | |
| 2010–2019 | 135 (57.0) | 122 (62.2) | 118 (84.3) | |
| Lymph Nodes Resected | 0.401 | |||
| Median (interquartile range) | 2 (1–4) | 2 (1–4) | ||
| Mean (range) | 3.30 (1–16) | 3.02 (0–26) | ||
| Nodal status, N (%) | 0.002* | |||
| N1 | 38 (16.0) | 56 (28.6) | ||
| N0 | 98 (41.4) | 81 (41.3) | ||
| NX | 101 (42.6) | 59 (30.1) | ||
| Locoregional Lymphadenopathy, N (%) | 45 (19.1) | 48 (24.5) | 57 (40.7) | <0.001* |
*
P<0.05
a
First HAIP was placed in 2001
HAIC = hepatic arterial infusion chemotherapy, HAIP = hepatic arterial infusion pump, SYS = systemic chemotherapy