. Author manuscript; available in PMC: 2022 Jan 15.

Published in final edited form as: Clin Cancer Res. 2021 May 7;27(14):4101–4108. doi: 10.1158/1078-0432.CCR-21-0412

Table 2.

Cox proportional hazards and Wald test for univariable and multivariable survival models.

Variable	Univariable Model			Multivariable Model
Variable	Hazard Ratio	95% C.I.	P-Value	Hazard Ratio	95% C.I.	P-Value
Age	1.00	1.0–1.0	>0.95
Female Sex (Ref. male)	0.91	0.72–1.14	0.407
Nonwhite race (Ref. white)	0.95	0.7–1.4	0.792
Well differentiated (Ref. poorly differentiated)	0.64	0.23–1.73	0.374
Moderately differentiated (Ref. poorly differentiated)	0.71	0.55–0.90	0.005^*
Tumor size	1.09	1.06–1.12	<0.001^*	1.05	1.01–1.08	0.009^*
≥ 1 lymph node with metastasis	2.41	1.8–3.2	<0.001^*
Multifocal liver disease	2.35	1.9–3.0	<0.001^*	1.61	1.2–2.1	<0.001^*
Interaction Terms	Univariable			Multivariable
HAIC when N0 (Ref. resection)	2.88	2.2–3.8	<0.001^*	2.09	1.6–2.8	<0.001^*
HAIC when N1 (Ref. resection)	1.17	0.7–1.9	<0.001^*	0.81	0.5–1.3	<0.001^*

P<0.05

HAIC = hepatic arterial infusion chemotherapy, SYS = systemic chemotherapy