Table 2.
Adverse events attributed to adavosertib.
| Adverse event | Grade 1-2 (%) | Grade 3 (%) | Grade 4 (%) |
|---|---|---|---|
| Hematological | |||
| Anemia | 20 (47%) | 9 (21%) | — |
| Leukopenia | 12 (29%) | 5 (12%) | 4 (10%) |
| Lymphopenia | 18 (43%) | 12 (29%) | — |
| Neutropenia | 5 (12%) | 4 (10%) | 5 (12%) |
| Febrile neutropenia | — | 1 (2%) | — |
| Thrombocytopenia | 13 (31%) | 5 (12%) | 1 (2%) |
| Gastrointestinal | |||
| Anorexia | 17 (40%) | — | — |
| Diarrhea | 25 (60%) | 2 (5%) | — |
| Nausea | 31 (74%) | 3 (7%) | — |
| Vomiting | 24 (57%) | 5 (12%) | — |
| Electrolyte | — | ||
| Hypocalcemia | 3 (7%) | 1 (2%) | — |
| Hypomagnesemia | 7 (17%) | 1 (2%) | — |
| Hyponatremia | 8 (19%) | 1 (2%) | — |
| Hypophosphatemia | 10 (24%) | 6 (14%) | — |
| Hypokalemia | 5 (12%) | 1 (2%) | |
| Infection | |||
| Upper respiratory infection | — | 1 (2%) | — |
| Investigations | |||
| Alanine aminotransferase increased | 11 (26%) | — | — |
| Aspartate aminotransferase increased | 11 (26%) | — | — |
| Other | |||
| Fatigue | 19 (45%) | 3 (7%) | — |
| Dehydration | 5 (12%) | 1 (2%) | — |
| Hypoalbuminemia | 9 (21%) | — | — |
The percentage of patients experiencing each event is noted in parentheses (n = 42 patients).