(A): Observed species index (Kruskal-Wallis test, X2 = 7.861 P = 0.049) (B): ACE index (Kruskal-Wallis test, X2 = 8.537 P = 0.036). (C): Chao 1 index (Kruskal-Wallis test, antibiotics: X2 = 6.631 P = 0.085). (D): PCA analysis of gut bacteria data R = 0.3241 P = 0.001) Data are shown as mean ± S.E.M. (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001. NS: not significant. FMT: fecal microbiota transplantation. NS: not significant. WT + FMT-C: Wild-type mice+ FMT from control (no CSDS) mice. WT + FMT-S: Wild-type mice + FMT from CSDS susceptible mice. KO + FMT-S: Ephx2 KO mice + FMT from CSDS-susceptible mice. KO + FMT-C: Ephx2 KO mice + FMT from control (no CSDS) mice.