Table 1:
Demographic and clinical characteristics of the participants.
| MDD (n=110) |
Healthy Controls (n=27) |
Psych Controls (n=23) |
P Value | |
|---|---|---|---|---|
| Age, mean (sd) | 19.5 (0.4) | 20.3 (0.2) | 19.1 (0.4) | <0.006 |
| Female, n (%) | 72 (65) | 10 (37) | 10 (43) | <0.010 |
| White Race, n (%) | 89 (86) | 24 (89) | 20 (87) | >0.90 |
| Hispanic, n (%) | 9 (9) | 2 (7) | 3 (9) | >0.90 |
| Vaginal delivery, n (%) | 76 (78) | 21 (91) | 17 (74) | >0.30 |
| Overweight/Obese, n (%) | 26 (24) | 9 (33) | 8 (35) | >0.50 |
| Antibiotic use, n (%) | 8 (7) | 2 (7) | 1 (4) | >0.90 |
| Alcohol Use, n (%) | 86 (83) | 17 (63) | 16 (70) | <0.060 |
| MDD Status, n (%) | <0.0001 | |||
| Taking SSRI, n (%) | 43 (39) | 0 | 3 (13) | <0.0001 |
| Trajectory Group, n (%) | <0.0001 |
MDD: major depressive disorder, Psych Controls: psychiatric controls.
Missing data: Race (6), Ethnicity (6), Vaginal Delivery (16), Trajectory Group (7), Alcohol Use (6)
“Antibiotic Use” relates to use within 6 to 12 months prior to study entry, given that use within the past 6 months led to exclusion.
Trajectory group 1) participants with no depressive symptoms, 2) participants with low-level depressive symptoms, 3) participants in episode, remitting during the course of the study, and 4) participants persisting in episode during the course of the study.
sd= standard deviation