Table 4.

Seed-to-voxel analyses (including only participants pre- and post-treatment scans; n=56) showing clusters with significant decreases in connectivity pre- to post-treatment across all participants controlling for age and sex. Seed time-series was derived from the mean of 65 ROIs labeled as part of the Default Mode Network in the Seitzman-300 ROI atlas.

MNI (x,y,z)	Brain Region(s)	Cluster Size	Num. Peaks	TFCE	p-FWE	peak-FDR	peak p-uncorrected
−18, 30, 40	Left Superior Frontal Gyrus, Left Middle Frontal Gyrus, Left Frontal Pole	1699	69	1579.8	0	0.000018	0
−40, −70, 34	Left Lateral Occipital Cortex, Left Angular Gyrus	1062	33	1246.95	0.0018	0.005154	0.000008
6, 38, −4	Left Frontal Pole, Frontal Medial Cortex, Bilateral Paracingulate Gyrus, Right Frontal Pole, Anterior Cingulate Gyrus	2068	119	1208.42	0.002	0.005154	0.000012
−8, −54, 20	Precuneus Cortex, Posterior Cingulate Gyrus	1171	53	991.99	0.0094	0.005154	0.000078
12, 34, 20	Right Paracingulate Gyrus	94	3	762.08	0.0348	0.009896	0.00039
20, 64, 20	Right Frontal Pole	101	3	713.69	0.0468	0.012461	0.000544
−2, 40, 4	Anterior Cingulate Gyrus	3	1	710.22	0.048	0.012486	0.000558

Note. FDR – False Discovery Rate, FWE – Family Wise Error, MNI – Montreal Neurological Institute, ROI – Region of Interest, TFCE – Threshold Free Cluster Enhancements