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. 2021 Jul 15;11:14516. doi: 10.1038/s41598-021-93893-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ELISA validation of candidate biomarkers. (a) Validation of the 4 candidate protein biomarkers. Left panels: box plots showing that the signal intensities of the four candidate biomarkers are significantly higher in the ATB group than in the HC and LTBI control groups. Right panels: ROC curves. The sensitivity and specificity values obtained at the optimal cut off value are shown for each protein. (b) Performance of the top biomarker panel, comprised of Rv0934, Rv3881c, Rv1860, and Rv1827. Orange and light blue lines represent samples scored as positives and negatives, respectively. A sample was predicted as ATB positive when any of the four proteins in the panel was positive. The heatmap was drawn using the ‘pheatmap’ package (v1.0.12)²³.