Fig. 5. Deficiency of both GPX4 and vitamin E impairs hematopoietic system homeostasis.

a The body weight, b spleen weight, and c total BM cell counts of the Gpx4^flox/flox Vav-Cre mice were measured after 3 weeks of a V_E-depleted diet. d Left panel: representative flow cytometric plots of the T cell, B cell, and myeloid cell groups in peripheral blood. Right panel: statistical data. e The number of HSPCs in the Gpx4^flox/flox Vav-Cre mice after 3 weeks of a V_E-depleted diet. N = at least four mice in each group. Data are the mean ± SD. (*P < 0.05, **P < 0.01, ***P < 0.001).