Table 1.
Patient characteristics.
| Autopsy diagnosis category | ID | Clinical diagnosis | Cause of death | Age at death (y) | Gender | Autopsy diagnosis | ABC score | Frontal cortex: Aβ/α-syn/TDP-43/FUS | Postmortem delay (h) | Fixation time (d) | APOE |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AD | 1 | AD | Pneumonia | 75 | Female | AD, CAA | A3/B3/C3 | + /–/–/ n.s. | <12 | 138 | E3/E3 |
| 2 | AD | n.s. | 79 | Female | AD, CAA, vascular lesions | A3/B3/C3 | + /–/–/ n.s. | 20 | 44 | E3/E4 | |
| 3 | CBS | n.s. | 73 | Female | AD, CAA | A3/B3/C3 | +/–/–/ n.s. | 36 | >60 | E4/E4 | |
| 4 | Dementia n.s | Pyelonephritis | 88 | Female | AD, vascular lesions | A3/B3/C3 | + /–/–/ n.s. | 54 | 229 | E3/E4 | |
| 5 | AD, PD | n.s. | 63 | Male | AD, CAA, vascular lesions | A3/B3/C3 | + /–/–/ n.s. | 21 | 76 | E3/E3 | |
| 6 | AD | n.s. | 70 | Male | AD, CAA | A3/B3/C3 | + /–/–/ – | 24 | 190 | E3/E3 | |
| PSP | 7 | PSP | n.s. | 85 | Female | PSP | A0/B1/C0 | –/–/ n.s. / n.s. | 15 | n.s. | E2/E3 |
| 8 | AD+PD | Terminal dementia | 84 | Female | PSP, atherosclerosis | A0/B0/C0 | –/–/ n.s. / n.s. | 8 | n.s. | n.s. | |
| 9 | FTD (CBS) | Cerebral hemorrhage | 78 | Female | PSP, AGD, multiple cerebral hemorrhages | A0/B2/C0 | – /–/–/ n.s. | 24 | 76 | E3/E3 | |
| 10 | PSP | Terminal dementia | 67 | Female | PSP | A0/B0/C0 | –/–/–/ – | 7 | 80 | E3/E3 | |
| 11 | PSP | Cachexia | 67 | Male | PSP | A0/B1/C0 | –/–/–/ – | 38 | 195 | n.s. | |
| HC | 12 | NNPD, | Pulmonary embolism | 46 | Female | NNPF | A0/B1/C0 | –/–/ n.s. / n.s. | 17 | 3 | E2/E3 |
| 13 | NNPD | Sudden cardiac death | 53 | Male | NNPF | n.s./B1/C0 | –/–/ n.s. / n.s. | 22 | 5 | E3/E3 | |
| 14 | NNPD, CHD, DM | MI | 61 | Male | NNPF | A0/B1/C0 | –/–/–/ – | 22 | 7 | E3/E3 | |
| 15 | NNPD, CHD | MI | 85 | Female | NNPF | A0/B1/C0 | –/–/ n.s. / n.s. | 20 | 13 | E3/E3 | |
| 16 | NNPD, CHD | MI | 46 | Male | NNPF | n.s./B0/C0 | –/–/ n.s. / n.s. | 22 | 10 | E3/E4 |
AD, Alzheimer's disease; PSP, progressive supranuclear palsy; HC, healthy control; CBS, corticobasal syndrome; PD, Parkinson's disease; FTD, frontotemporal dementia; NNPD, no neurological/psychiatric disease; CHD, coronary heart disease; DM, diabetes mellitus; MI, myocardial infarction; CAA, cerebral amyloid angiopathy; AGD, agyrophilic grain disease; NNPF, no neuropathological findings; ABC-score, Amyloid Braak CERAD (Consortium to Establish a Registry for Alzheimer's Disease); Aβ, amyloid-β; α-syn, α-synuclein; TDP-43, Transactive response DNA binding protein 43 kDa; FUS, fused in sarcoma; n.s., not specified.