Table 3.

Comparison of Pros/Cons among imaging modalities.

		Pros	Cons	Label	Properties of Measures [98]
					Sensitivity	Spatial Resolution
Imaging Modality	PET/SPECT	High sensitivity 3D image Quantitative Translational Probe variety Molecular specific Whole body scan Good deep part image	Facility limitation (RI) Lack of anatomical information (⇒Complementary with CT/MRI) Expensive Half life of nuclide Radiation exposure	Passive diffusion:89Zr-oxine; 111In-oxine; 99mTc-HMPO Transporter:18FDG Reporter: HSV1-tk/18F-FHBG; NIS/123I	High	Preclinical PET: ~1 mm Clinical PET: 4–6 mm Preclinical SPECT: 1–2 mm Clinical SPECT: 5–8 mm
	MRI	3D image Translational Good soft tissue contrast Anatomical information available Good deep part image	Body motion artifact Low throughput Narrow FOV Expensive	Negative Contrast Agent: SPIO Positive Contrast Agent:19F, Gd Reporter: Ferritin	Moderate	Preclinical MRI: 25–250 μm Clinical: 0.5–5 mm, 1–3 mm3