Table 9.
Pharmacokinetic parameters of photochemicals.
| Drug Candidate | Human Intestinal Absorption (+ve/-ve) | Human oral bioavailability (+ve/-ve) | Blood Brain Barrier (+ve/-ve) | P-glycoprotein substrate/inhibitor | Subcellular localization | CYP substrate | CYP Inhibitor | Carcinogenicity (binary) (+ve/-ve) |
Fish aquatic toxicity (+ve/-ve) | Water solubility Logs |
Acute Oral Toxicity (kg/mol) | Tetrahymena pyriformispIGC50 (ug/L) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IL01 | + | - | + | −/− | Mitochondria | - | - | - | 0.746 | -1.138 | 2.657 | 0.284 |
| IL 02 | + | - | + | −/− | Mitochondria | - | - | - | 2.782 | -1.854 | 1.842 | -0.266 |
| IL 03 | + | - | + | −/− | Mitochondria | - | - | - | 2.510 | -1.847 | 1.972 | 0.171 |
| IL 04 | + | - | + | −/− | Mitochondria | - | - | - | 2.121 | -2.038 | 2.217 | 0.273 |
| IL 05 | + | - | + | −/− | Mitochondria | - | - | - | 1.632 | -2.200 | 2.545 | -0.071 |
| IL06 | + | - | + | −/− | Mitochondria | - | - | - | 1.894 | -2.490 | 2.044 | 0.315 |
| IL 07 | + | - | + | −/− | Mitochondria | - | - | - | 1.473 | -2.882 | 2.215 | 0.192 |
| IL08 | + | - | + | −/− | Mitochondria | - | - | - | 1.681 | -2.928 | 2.224 | 0.436 |