Table 11.
Docking results of ligands L5, L16, L46 and ligand reference Lref (Crizotinib) at receptor c-Met sites.
| Ligands | Complex | Binding Energy (kcal/mol) | Hydrogen-Binding Interaction |
Hydrophobic Interaction |
|---|---|---|---|---|
| Lref | Lref-A | -7.02 | Met1160, Pro1158, Asp1222, Ile1084 | Ala1108, Ala1221, Ala1226, Leu1157, Leu1140, Tyr1230, Val1092, Met1211 |
| L5 | X-A | -7.08 | Tyr1159, Met1160, Ile1084 | Met1211, Tyr1230 |
| L16 | X–B | -8.27 | Gly1163, Met1160, Tyr1159 | Ile1084, Ala1108, Val1092, Tyr1230 |
| L46 | X–C | -7.40 | Met1160, Tyr1159, Lys1161, His1162 | Ile1084, His1162 |