Table 5.
Stability of analytes in human plasma.
| Analytes | Concentration (ng/mL)a | Stability (RSD%) |
||||
|---|---|---|---|---|---|---|
| Short-term (4 h at room temperature) | Short-term (4 h at 4 °C) | Long-term (30 d at -40 °C) | 24 h at auto-sampler (4 °C) | Three freeze-thaw | ||
| INH | 120 | 5.27 | 7.81 | 10.01 | 10.59 | 10.81 |
| 4800 | 7.55 | 7.29 | 7.69 | 5.84 | 9.25 | |
| RIF | 500 | 11.67 | 7.07 | 13.14 | 4.38 | 11.27 |
| 20 000 | 8.74 | 5.14 | 8.75 | 6.84 | 8.06 | |
| EMB | 240 | 3.54 | 4.73 | 5.84 | 3.04 | 4.90 |
| 9600 | 6.77 | 6.95 | 6.53 | 6.72 | 6.34 | |
| PZA | 1200 | 1.62 | 2.70 | 2.25 | 2.03 | 3.18 |
| 48 000 | 2.00 | 3.46 | 3.24 | 2.28 | 2.33 | |
| AC-INH | 480 | 5.79 | 8.17 | 4.75 | 2.71 | 5.88 |
| 19 200 | 5.08 | 7.72 | 3.32 | 5.04 | 6.06 | |
a
The top and bottom QC samples are the LQC and HQC, respectively.