Table 6.

Clinical information and drug concentrations in patients with TB.

No.	Age (y)	Sex	Weight	GFR (mg/mL)	Cr (μmol/L)	ALT (U/L)	AST (U/L)	Concentration (ng/mL)
								INH∗	AC-INH∗	RIF	EMB	PZA∗
1	36	F	40	157.579	36.38	7	12	24	ND	ND	187	6340
								319	96	ND	347	7570
2	28	M	45	198.124	46.29	11	14	ND	ND	7190	1740	ND
								ND	ND	6050	1890	ND
3	39	M	50	164.959	51.27	15	9	ND	ND	3660	429	ND
								ND	ND	1590	307	ND
4	40	M	50	125.781	64.85	37	30	35	96	463	540	30900
								24	ND	ND	311	22300
5	27	M	60	271.573	24.03	8	15	24	ND	1830	149	4400
								16600	2110	229	1170	28500
6	42	M	53.7	103.846	75.91	22	20	70.7	ND	ND	694	ND
								2120	768	953	607	ND
7	50	M	45	311.587	28.41	8	20	24	ND	9800	1230	ND
								ND	ND	4840	1100	ND
8	35	M	40	318.622	29.67	23	27	24	96	899	183	ND
								24	ND	634	183	ND
9	56	M	60	155.643	50.82	41	37	45.5	848	1320	794	31900
								24	491	713	595	28900
10	68	M	60	190.895	41.15	43	43	47.5	613	4790	364	29900
								12100	2880	3280	667	34800
11	51	M	52	219.322	38.38	13	20	24	ND	ND	2130	27500
								6590	1610	ND	1230	20000
12	72	M	62	91.702	76.9	21	22	406	248	9310	450	18700
								1830	1140	3710	1630	25300
13	35	M	60	155.401	51.05	18	21	308	96	4720	237	9100
								864	753	4160	1080	12500
14	36	M	48	127.198	65.11	40	38	24	ND	ND	ND	ND
								24	ND	ND	ND	ND
15	68	M	60	149.492	50.86	10	7	ND	ND	ND	587	ND
								ND	ND	ND	870	ND
16	64	M	58	163.294	50.09	38	26	4520	924	ND	942	240
								3660	1040	ND	1600	240
Average	46.7		52.7	181.56	48.823	22.19	22.56	1990.23	863.06	3507.05	808.10	18838.33
Min	27		40	91.702	24.03	7	7	24	96	229	149	240
Max	72		62	318.622	76.9	43	43	16600	2880	9800	2130	34800

ND: not detected. GFR, glomerular filtration rate; Cr, plasma creatinine; ALT, Alanine aminotransferase; AST, aspartate aminotransferase.

^∗For the concentration less than LLOQ, 1/2 LLOQ was recorded, with 24 ng/mL for INH, 96 ng/mL for AC-INH, and 240 ng/mL for PZA.