Figure 2.

Dox treated mice displayed deficits in spatial memory assessed with the Y-maze. (A) Schematic representation of the Y -maze procedure. (B) Total number of arm entries during testing revealed no differences in overall activity. (C) percentage of entries into the Novel arm during testing revealed a decreased response to novelty in Dox-treated animals, and a significant treatment x arm interaction. (D) Number of alternations revealed no deficits in spatial working memory. (E) Percent time spent in novel arm during testing revealed attenuated exploratory behavior in Dox-treated animals, and a significant treatment x arm interaction. Bars represent mean ± SEM; ∗p < .05, ∗∗p < 0.005; n = 5 animals in Dox group and 6 animals in control group.