TABLE 3.

Top T2D SNPs nominally associated with IROD2 cluster in individuals with long-term diabetes.

SNP	Gene	Chr	BP	Risk allele	RAF	IROD2 vs. all clusters		IROD2 vs. IROD1		IROD2 vs. SIDD		IROD2 vs. MARD
						OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
rs7903146	TCF7L2	10	114758349	T	0.28	0.54 (0.39, 0.74)	0.0001*	0.61 (0.42, 0.88)	0.008	0.54 (0.37, 0.77)	0.001*	0.45 (0.31, 0.65)	0.0003*
rs163184	KCNQ1	11	2847069	G	0.50	0.67 (0.52, 0.88)	0.003	0.60 (0.44, 0.82)	0.001	0.74 (0.54, 1.01)	0.059	0.71 (0.52, 0.98)	0.036
rs10923931	NOTCH2	1	120517959	T	0.13	0.49 (0.30, 0.80)	0.004	0.52 (0.29, 0.90)	0.020	0.50 (0.29, 0.87)	0.014	0.45 (0.26, 0.78)	0.004
rs6795735	ADAMTS9	3	64705365	C	0.59	0.72 (0.56, 0.93)	0.012	0.68 (0.50, 0.93)	0.015	0.78 (0.58, 1.06)	0.113	0.72 (0.53, 0.97)	0.033
rs11634397	ZFAND6	15	80432222	G	0.66	0.73 (0.56, 0.94)	0.016	0.71 (0.51, 0.99)	0.041	0.70 (0.51, 0.96)	0.025	0.76 (0.56, 1.03)	0.081
rs16927668	PTPRD	9	8369533	T	0.18	1.40 (1.03, 1.91)	0.033	1.45 (1.00, 2.10)	0.047	1.53 (1.04, 2.24)	0.032	1.25 (0.85, 1.82)	0.255
rs4299828	ZFAND3	6	38177667	A	0.81	0.73 (0.54, 0.99)	0.042	0.65 (0.46, 0.93)	0.018	0.80 (0.55, 1.15)	0.227	0.79 (0.55, 1.13)	0.195
rs459193	ANKRD55	5	55806751	G	0.72	1.36 (1.01, 1.84)	0.044	1.30 (0.90, 1.86)	0.159	1.32 (0.92, 1.88)	0.128	1.44 (1.01, 2.07)	0.045

Association of T2D SNPs with IROD2 cluster as case group. OR and 95% CI were calculated using logistic regression adjusted for sex and age. Chr, chromosome; BP, base pair; RAF, risk allele frequency. Number of individuals in the analyses IROD2 vs. all clusters: n = 837, IROD2 vs. IROD1: n = 357, IROD2 vs. SIDD: n = 355, IROD2 vs. MARD: n = 415. *Significant after adjustment for the multiple testing using Bonferroni correction (p < 0.05).