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. 2021 Jul 2;9:686675. doi: 10.3389/fcell.2021.686675

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Copyright © 2021 Zhang, Shen, Cai, Yu, Yang, Wu, Zhu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The expression level of CTLA4, PDCD1, CD274, and CD19 in high-/low-risk subtypes in TCGA cohort. (B,C) Waterfall maps of eight mutated genes in high-/low-risk subtypes. (D) The difference of tumor mutational burden between the high- and low-risk subtypes. (E) Gene set enrichment analysis (GSEA) showed the tumor hallmarks enriched in the high-risk subgroup and the relevance between biological process, molecular function, and hallmarks and m⁶A-LPS. (F) Heatmap of the correlations between four immune targets and the 12 prognostic m⁶A-related lncRNAs. (G) Kaplan–Meier curves of OS for BRCA patients in the chemotherapy subgroup. (H) ROC curve for patients with chemotherapy. TCGA, The Cancer Genome Atlas; OS, overall survival; BRCA, breast cancer; ROC, receiver operating characteristic; lncRNAs, long non-coding RNAs.