TABLE 2.
Ventilation during NREM and REM sleep in NZO mice at baseline and after the treatment with leptin receptor blocker Allo-aca or control peptide Gly11.
| Gly11 (n = 7) |
Allo-aca (n = 6) |
||||
| Baseline | Treatment | Baseline | Treatment | ||
| NREM | VT (mL) | 0.3 ± 0.0 | 0.4 ± 0.0 | 0.3 ± 0.1 | 0.3 ± 0.1 |
| RR (bpm) | 107.5 ± 5.9 | 111.6 ± 5.0 | 95.9 ± 6.4 | 90.7 ± 5.4* | |
| VImax (mL/S) | 3.1 ± 0.3 | 3.1 ± 0.3 | 2.9 ± 0.5 | 2.1 ± 0.4 | |
| MIFR (mL/s) | 2.0 ± 0.3 | 2.0 ± 0.3 | 1.8 ± 0.3 | 1.3 ± 0.3 | |
| Inspiratory DC | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 | |
| IFL (%) | 4.8 ± 1.3 | 8.0 ± 2.3 | 4.4 ± 1.4 | 7.5 ± 2.5 | |
| Mean SpO2 (%) | 95.7 ± 0.7 | 95.6 ± 0.8 | 97.0 ± 0.5 | 97.0 ± 0.5 | |
| REM | VT (mL) | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.2 ± 0.0 |
| RR (bpm) | 122.7 ± 5.3 | 123.6 ± 5.0 | 118.3 ± 5.8 | 116.1 ± 5.4 | |
| VImax (mL/s) | 2.8 ± 0.4 | 2.7 ± 0.3 | 2.5 ± 0.4 | 1.8 ± 0.3 | |
| MIFR (mL/s) | 1.6 ± 0.2 | 1.6 ± 0.2 | 1.5 ± 0.2 | 1.1 ± 0.2 | |
| Inspiratory DC | 0.4 ± 0.0 | 0.4 ± 0.0 | 0.3 ± 0.0 | 0.3 ± 0.0 | |
| IFL (%) | 18.3 ± 3.6 | 23.7 ± 4.7 | 16.6 ± 3.9 | 19.3 ± 5.1 | |
| Mean SpO2 (%) | 92.3 ± 1.0 | 92.1 ± 1.0 | 94.5 ± 1.0 | 95.2 ± 1.0 | |
| Apneas (events/h) | 31.4 ± 5.4 | 26.7 ± 5.3 | 31.8 ± 5.6 | 33.7 ± 5.1 | |
| ODI (events/h) | 8.4 ± 1.5 | 7.0 ± 1.4 | 6.2 ± 1.5 | 7.4 ± 1.4 | |
Mean values ± standard errors are shown. VT, tidal volume; RR, respiratory rate; VImax, maximum inspiratory flow; MIFR, mean inspiratory flow rate; DC, duty cycle; IFL, inspiratory flow limitation; SpO2, oxyhemoglobin saturation; ODI, oxygen desaturation index. Mixed regression model. *P < 0.05 compared to control group.