Fig. 3.

Drug-to-Drug interactions profiling by the FDA. Drug-to-drug interactions determined by the FDA labelled between COVID-19 treatment drugs and (A) anti-infection agents, (B) cardiovascular medicines, (C) anticancer agents, (D) antipsychotic agents. According to the legends, the circles indicate drugs in the COVID-19 regimens, while the diamonds indicate drugs in the basic regimens. Among them, the red circles, green circles and the orange circles are antiviral agents, immunomodulators and other drugs in the COVID-19 regimens respectively. Similarly, dark blue diamonds, indigo blue diamonds, violet diamonds and yellow diamonds represent anti-infection agents, cardiovascular drugs, anticancer agents and anti-psychotic agents respectively. If there is a DDI between two drugs, these two drugs are linked by a line. The red line indicates that this DDI can generate toxicity, while the green line indicates that this DDI can impact the efficacy by increasing or decreasing the concentration as listed in Table S2