Table 1.
Baseline demographics and clinical characteristics of TG patients.
| Variables | Overall (n = 165) | PU <0.3 g/24 h (n = 40) | PU ≥0.3 g/24 h (n = 125) | P-value* |
|---|---|---|---|---|
| Age at the time of Tx (years) | 43.65 ± 15.18 | 46.60 ± 15.37 | 42.71 ± 15.06 | 0.159 |
| Male sex | 94 (56.97) | 21 (52.5) | 73 (58.4) | 0.512 |
| Prior transplantation | 38 (23.03) | 7 (17.5) | 31 (24.8) | 0.578 |
| Deceased donor organ | 101 (61.21) | 25 (62.5) | 76 (60.8) | 0.848 |
| Cold ischemia time (h) | 11.00 (3.50, 31.12) |
14.00 (4.20,24.00) |
10.20 (3.50, 31.12) |
0.215 |
| HLA mismatches | 3.09 ± 1.42 | 2.95 ± 1.47 | 3.14 ± 1.40 | 0.463 |
| Peak PRA (%) | 0.00 (0.00, 100.00) |
0.00 (0.00, 70.00) |
0.00 (0.00, 100.00) |
0.026 |
| Peak PRA ≥5% | 35 (21.21) | 3 (7.50) | 32 (25.60) | 0.015 |
| Pre-transplant PRA (%) | 0.00 (0.00, 98.00) |
0.00 (0.00, 65.00) |
0.00 (0.00, 98.00) |
0.139 |
| Pre-transplant PRA ≥5% | 19 (11.52) | 2 (5) | 17 (13.60) | 0.139 |
| Etiology of ESRD | ||||
| Glomerulonephritis Interstitial nephritis Polycystic disease Htn/nephrosclerosis Diabetic nephropathy Other causes Unknowing etiology |
30 (18.18) 21 (12.73) 10 (6.06) 11 (6.67) 12 (7.27) 35 (21.21) 46 (27.88) |
6 (15) 6 (15) 2 (5) 4 (10) 1 (2.5) 11 (27.5) 10 (25) |
24 (19.2) 15 (12) 8 (6.4) 7 (5.6) 11 (8.8) 24 (19.2) 36 (28.8) |
0.639 |
| Baseline Cr (mg/dL)** | 1.63 ± 0.64 | 1.46 ± 0.56 | 1.69 ± 0.66 | 0.052 |
| Delayed graft function | 50 (30.3) | 6 (15) | 44 (35.2) | 0.021 |
Data are presented as mean ± SD, median (minimum, maximum), or n (%).
*
P-values indicated group differences for proteinuria <0.3 g/24 h compared with proteinuria ≥0.3 g/24 h.
**
Three months after transplantation.
TG, transplant glomerulopathy; PU, proteinuria; Tx, transplantation; HLA, human leukocyte antigen; PRA, panel reactive antibody; ESRD, end-stage renal disease; Htn, hypertension; Cr, creatinine. Bold values indicated statistical significance.