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. 2021 May 18;8(7):1422–1432. doi: 10.1002/acn3.51381

FIGURE 2.

FIGURE 2

Functional analysis of KCNH2 variants from epilepsy control cohort. Sample recording traces of Kv11.1 variant channels (top) and average normalized conductance–voltage relationships (below) comparing Kv11.1 WT and variant channels for (A) A913V (B) G903R, (C) K897R, (D) S871C, (E) T436M, (F) R397H, (G) P347S, (H) D259N (I), A193V, and (J) S140F variants. (K) Average maximal amplitude for each variant in the epilepsy control cohort. Number in each bar represents the number of independent oocytes recorded for each variant. Black and red dashed lines indicate 100% and 80%, respectively, of maximal current amplitude of the Kv11.1 WT channel. *p < 0.05, **p < 0.01.