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. 2021 May 13;30(15):1398–1412. doi: 10.1093/hmg/ddab136

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Vivo-PMO PACS4 treatment down-regulates expression of DUX4 and relevant genes. Following TMX-induced DUX4 expression and four weekly treatments with Vivo-PMOs, changes at mRNA levels in TA muscle were examined by RT-qPCR for DUX4 (A), Trim36 (B), Wfdc3 (C), Myh3 (D) and Pax7 (E), relative to corresponding Gapdh expression. Data are shown as means ± SEM; n = 4–5. Statistical comparison was by one-way ANOVA followed by Tukey’s multiple comparisons test, P < 0.05 (^*), P < 0.01 (^*^*), P < 0.001 (^*^*^*), P < 0.0001 (^*^*^*^*).