Table 2.
Association of ΔAF and ΔLD with the degree of heterogeneity considering GWAS index variants with concordant and discordant heterogeneity
| Heterogeneity | Variable | MBLM | LOESS–GAM | |||
|---|---|---|---|---|---|---|
| V-value | Pr (>|V|) | F-value | Pr (>|t|) | |||
| Concordant | ΔAF EUR versus | AFR | 997 | 0.714 | — | — |
| AMR | 1122 | 0.206 | — | — | ||
| CSA | 998 | 0.709 | — | — | ||
| EAS | 1113 | 0.23 | — | — | ||
| MID | 1564 | 9.04E-06 | 1564 | 9.04E-06 | ||
| ΔLD EUR versus | AFR | 577 | 8.21E-03 | 577 | 8.21E-03 | |
| AMR | 1417 | 7.17E-04 | 1417 | 7.17E-04 | ||
| CSA | 518 | 2.16E-03 | 518 | 2.16E-03 | ||
| EAS | 1175 | 0.1 | — | — | ||
| Discordant | ΔAF EUR versus | AFR | 145 | 0.00769 | 6.32 | 0.026 |
| AMR | 108 | 0.338 | — | — | ||
| CSA | 21 | 5.31E-03 | 2.48 | 0.140 | ||
| EAS | 50 | 0.127 | — | — | ||
| MID | 69 | 0.486 | — | — | ||
| ΔLD EUR versus | AFR | 31 | 0.0159 | 1.13 | 0.308 | |
| AMR | 46 | 0.089 | — | — | ||
| CSA | 16 | 2.65E-03 | 0.11 | 0.744 | ||
| EAS | 70 | 0.514 | — | — | ||
V-value: the intercept value of the Theil-Sen regression; Pr (>|V|): p-value of the Theil-Sen regression slope; F-value: statistics related to the V-test; Pr(>|F): p-value for the t-test.